Neuronal Signaling

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  1. Varenicline

    Catalog No. A10966
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    nAChR partial agonist
    Varenicline是烟碱样受体部分激动剂。 了解更多
  2. Varenicline Hydrochloride

    Catalog No. A21539
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    α4β2 nAChR partial agonist
    Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. 了解更多
  3. PNU 282987

    Catalog No. A11233
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    α7 nAChR 激动剂
    PNU 282987 (PNU-282,987)可作为神经烟碱乙酰胆碱受体α7亚型的有效选择性激动剂。 了解更多
  4. Ispronicline (TC-1734, AZD-3480)

    Catalog No. A14183
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    nAChR 激动剂
    Ispronicline (TC-1734,AZD-3480)是神经元烟碱乙酰胆碱受体部分激动剂。Ispronicline是亚型选择性的,主要与a4b2亚型结合。它具有抗抑郁、益智和神经保护作用。 了解更多
  5. Sofinicline (ABT-894, A-422894)

    Catalog No. A13842
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    nAChR 激动剂
    Sofinicline (ABT-894,A-422894)是一种新型的烟碱型乙酰胆碱受体激动剂,可治疗注意力不足/多动症。 了解更多
  6. ABT-418 HCl

    Catalog No. A13688
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    nAChR 激动剂
    ABT-418 HCl是神经元烟碱型乙酰胆碱受体激动剂。 了解更多
  7. 5-Iodo-A-85380 2HCl

    Catalog No. A13639
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    nAChR 激动剂
    5-Iodo-A-85380 2HCl是针对a4b2和a6b2烟碱乙酰胆碱受体的强效亚型选择性激动剂。 了解更多
  8. A-582941

    Catalog No. A13539
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    α7 nAChR 激动剂
    A-582941是选择性的AChR a7部分激动剂。它对大鼠和人类a7受体均表现出高亲和力(Ki值分别为10.8和16.7 nM)。 了解更多
  9. GTS-21 (DMBX-A)

    Catalog No. A15950
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    nAChR 激动剂
    GTS-21 dihydrochloride (DMBX-A)是一种选择性的α7烟碱乙酰胆碱受体激动剂,最近已被确定为一种有希望的炎症治疗方法。 了解更多
  10. LY2119620

    Catalog No. A14217
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    M2/M4 AChR 激动剂
    LY2119620是人M2和M4毒蕈碱乙酰胆碱受体的特异性变构激动剂。 了解更多
  11. Nitenpyram

    Catalog No. A14229
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    AchR 激动剂
    Nitenpyram是一种烟碱乙酰胆碱受体(AchR)激动剂。 了解更多
  12. Xanomeline oxalate

    Catalog No. A13685
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    mAChR 激动剂
    Xanomeline oxalate是毒蕈碱型乙酰胆碱受体的有效激动剂(M1,M2,M3,M4和M5的EC50值分别为0.3、92.5、5、52和42 nM)。 了解更多
  13. Cevimeline hydrochloride hemihydrate

    Catalog No. A15042
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    M1 激动剂
    Cevimeline hydrochloride hemihydrate是一种新型毒蕈碱受体激动剂,是干燥综合征干燥症的候选治疗药物。 了解更多
  14. TBPB

    Catalog No. A14205
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    M1 mAChR 激动剂
    TBPB是一种变构M1 mAChR激动剂,EC50值为89 nM,可调节淀粉样蛋白加工并在大鼠中产生类抗精神病药活性。 了解更多
  15. Cevimeline hydrochloride

    Catalog No. A18092
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    mAChR agonist
    Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. 了解更多
  16. Oxotremorine M iodide

    Catalog No. A21977
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    mAChR agonist
    Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. 了解更多
  17. Bethanechol chloride

    Catalog No. A10180
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    Muscarinic receptor 激动剂
    Bethanechol chloride是拟副交感神经的胆碱氨基甲酸酯,可选择性刺激毒蕈碱受体,而不会对烟碱样受体产生任何影响。 了解更多
  18. Metanicotine

    Catalog No. A11545
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    Nicotinic receptor 激动剂
    Metanicotine是一种神经元的尼古丁受体激动剂,对α4β2亚型具有高选择性(Ki = 26 nM)。选择性是α7受体(Ki = 36000 nM)的1,000倍以上。 了解更多
  19. Ibotenic Acid

    Catalog No. A14006
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    NMDA& mGlu receptor 激动剂
    Ibotenic Acid是最初从鹅膏菌属物种中分离出来的一种神经兴奋性氨基酸,它起着NMDA和代谢型谷氨酸受体激动剂的作用。 了解更多
  20. NMDA

    Catalog No. A12751
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    NMDA receptor 激动剂
    NMDA是一种原型NMDA受体激动剂。 了解更多
  21. AWD 131-138

    Catalog No. A13726
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    GABAA receptor 激动剂
    AWD 131-138是一种新的低亲和力的部分苯二氮卓类受体激动剂,在啮齿动物模型中具有强大的抗惊厥和抗焦虑特性。 了解更多
  22. Bretazenil

    Catalog No. A13784
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    GABAA 激动剂
    Bretazenil,苯二氮卓类受体局部激动剂,可预防OP中毒。 了解更多
  23. a5IA

    Catalog No. A14343
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    Benzodiazepine 激动剂
    a5IA是促智药物,它在GABAA受体的苯并二氮杂卓结合位点上起亚型选择性反向激动剂的作用。 了解更多
  24. Muscimol hydrobromide

    Catalog No. A13459
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    GABA(A) receptor 激动剂
    Muscimol hydrobromide是抗抑郁药氟西汀的活性代谢产物,可抑制5-羟色胺的摄取,pKi值为7.35.1。诺氟西汀的S-对映体的5-羟色胺再摄取阻断效能比R-对映体高20倍(分别为pKis = 7.86与6.51)。 了解更多
  25. Piperazine

    Catalog No. A16171
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    GABA receptor 激动剂
    Piperazine是由六元环组成的有机化合物,该六元环在环的相对位置包含两个氮原子。 了解更多
  26. Bamaluzole

    Catalog No. A17107
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    GABA receptor 激动剂
    Bamaluzole是GABA受体激动剂。 了解更多
  27. Afloqualone

    Catalog No. A17276
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    GABA receptor agonist
    Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多
  28. Homotaurine

    Catalog No. A17944
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    GABA receptor agonist
    Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. 了解更多
  29. Baclofen

    Catalog No. A18248
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    GABA agonist
    Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多
  30. CP-409092

    Catalog No. A20152
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    GABAA receptor partial agonist
    CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  31. TPA 023

    Catalog No. A20140
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    GABAA α2/α3 agonist
    TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. 了解更多
  32. RWJ-51204

    Catalog No. A12875
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    partial agonist of GABA(A) receptor
    RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. 了解更多
  33. MRK-016

    Catalog No. A12046
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    GABAA α5 receptor agonist
    MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS. 了解更多
  34. Acamprosate calcium

    Catalog No. A11308
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    GABA receptor agonist
    Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. 了解更多
  35. U-101017

    Catalog No. A13357
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    Benzodiazepine receptor/GABAA receptor agonist
    U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects. 了解更多
  36. (R)-Baclofen

    Catalog No. A16680
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    GABAB receptor agonist
    (R)-Baclofen(STX209) is a selective GABAB receptor agonist. 了解更多
  37. L-655708

    Catalog No. A21181
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    GABAA receptor inverse agonist
    L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). 了解更多
  38. CP-409092 hydrochloride

    Catalog No. A21397
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    GABAA receptor partial agonist
    CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  39. Gaboxadol hydrochloride

    Catalog No. A21730
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    GABAA receptors agonist
    Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects. 了解更多
  40. THIP

    Catalog No. A21738
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    δ-GABAAR agonist
    THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist. 了解更多
  41. AZD5423

    Catalog No. A13249
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    nonsteroidal glucocorticoid receptor 激动剂
    AZD5423是新型的非甾体类糖皮质激素受体激动剂。 了解更多

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