Membrane Transporters/Ion Channels

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  1. Rostafuroxin (PST-2238)

    Catalog No. A13283
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    Na+/K+ ATPase modulator
    Rostafuroxin (PST-2238)是一种哇巴因抑制剂,可对抗特定形式的高血压。 了解更多
  2. VX-809 (Lumacaftor)

    Catalog No. A10986
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    CFTR modulator
    VX-809 (Lumacaftor)是用于治疗囊性纤维化(CF)的第二种口服研究候选化合物,通过促进突变型CFTR(F508del-CFTR)的成熟,从而纠正囊性纤维症中常见的CFTR突变,在fisher大鼠甲状腺细胞中EC50为0.1 μM。 了解更多
  3. Caldaret

    Catalog No. A13148
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    intracellular Ca2+ handling modulator
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. 了解更多
  4. Astragaloside A

    Catalog No. A11405
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    Ca2+ signaling modulator
    Astragaloside A是缺氧条件下人脐静脉内皮细胞HIF-1α和通过PI3K/Akt途径血管生成的一种新型调节因子。 了解更多
  5. AUT1

    Catalog No. A18648
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    Kv3 potassium channel modulator
    AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). 了解更多
  6. CMPDA

    Catalog No. A21909
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    AMPA receptors positive allosteric modulator
    CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor. 了解更多
  7. PF-4778574

    Catalog No. A21157
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    AMPA receptor positive allosteric modulator
    PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. 了解更多
  8. JNJ-61432059

    Catalog No. A20209
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    AMPAR negative modulator
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. 了解更多
  9. PEPA

    Catalog No. A21904
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    AMPA receptors allosteric modulator
    PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. 了解更多
  10. CX546

    Catalog No. A21923
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    positive AMPAR modulator
    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. 了解更多
  11. Farampator

    Catalog No. A13798
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    AMPA receptor modulator
    Farampator是一种AMPA受体正调节剂,它可以改善短期记忆,但会损害情景记忆。 了解更多
  12. Biricodar dicitrate (VX-710 dicitrate)

    Catalog No. A13533
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    P-gp modulator
    Biricodar dicitrate (VX-710 dicitrate)是P-糖蛋白和MRP-1的调节剂;在多药耐药细胞中显示出有效的化学增敏活性。 了解更多
  13. LY335979 (Zosuquidar 3HCl)

    Catalog No. A10549
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    P-gp modulator
    LY335979 (Zosuquidar trihydrochloride)是一种强效高选择性P-gp抑制剂。 了解更多
  14. Biricodar

    Catalog No. A21464
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    P-glycoprotein/MRP-1 modulator
    Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells. 了解更多
  15. MRS1477

    Catalog No. A15498
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    TRPV1 modulator
    MRS1477是TRPV1阳性变构调节剂。 了解更多

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