DPP-4

Catalog No.Inhibitor Name DPP-4
A10848Sitagliptin phosphate monohydrate
**
A11224Linagliptin
****
A12528Vildagliptin (LAF-237)
***
A11109Saxagliptin
*
A13571Alogliptin
***
A14293Trelagliptin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

29 个项目

每页

设置升序顺序
  1. Vildagliptin dihydrate

    Catalog No. A21898
    Quick View
    DPP4 inhibitor
    Vildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1). 了解更多
  2. DBPR108

    Catalog No. A21833
    Quick View
    DPP4 inhibitor
    DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. 了解更多
  3. Dutogliptin

    Catalog No. A21573
    Quick View
    DPP4 inhibitor
    Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. 了解更多
  4. Gosogliptin

    Catalog No. A21566
    Quick View
    DPP-IV inhibitor
    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). 了解更多
  5. Diprotin A TFA

    Catalog No. A21475
    Quick View
    DPP IV inhibitor
    Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). 了解更多
  6. Teneligliptin hydrobromide hydrate

    Catalog No. A21465
    Quick View
    DPP-4 inhibitor
    Teneligliptin hydrobromide hydrate is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. 了解更多
  7. Gemigliptin

    Catalog No. A21285
    Quick View
    DPP4 inhibitor
    Gemigliptin is a highly selective dipeptidyl peptidase 4 (DPP4) inhibitor with a KD of 7.25 nM. 了解更多
  8. Saxagliptin hydrate

    Catalog No. A16694
    Quick View
    DPP4 inhibitor
    Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. 了解更多
  9. Talabostat

    Catalog No. A14079
    Quick View
    DPP-IV inhibitor
    Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM). 了解更多
  10. 1G244

    Catalog No. A18709
    Quick View
    DPP8/9 inhibitor
    1G244 is a novel potent and selective DPP8/9 inhibitor. 了解更多
  11. AZD7986

    Catalog No. A17095
    Quick View
    DPPI 抑制剂
    AZD7986,也称为INS 1007,是第二代可逆共价,有效和选择性DPP1抑制剂,潜在地可用于治疗慢性阻塞性肺疾病(COPD),其预测的人PK特性适用于每日一次人类给药。 了解更多
  12. Teneligliptin

    Catalog No. A15505
    Quick View
    DPP-4 抑制剂
    Teneligliptin是一种有效的DPP-4抑制剂,在体外竞争性抑制人血浆,大鼠血浆和人重组DPP-4,IC50值约为1 nM。 了解更多
  13. NVP DPP 728 dihydrochloride

    Catalog No. A15320
    Quick View
    DPP-4 抑制剂
    NVP DPP 728 dihydrochloride是一种有效的活性二肽基肽酶(DPP)-IV抑制剂,Ki和IC50值分别为11 nM和14 nM。 了解更多
  14. PK 44 phosphate

    Catalog No. A15309
    Quick View
    DPP-4 抑制剂
    PK 44 phosphate是二肽基肽酶IV(DPP-IV)的有效抑制剂,IC50值为15.8 nM。" 了解更多
  15. DPPI 1c hydrochloride

    Catalog No. A15298
    Quick View
    DPP-4 抑制剂
    DPPI 1c hydrochloride是一种双氰基吡咯烷化合物,可作为CD26(DPP 4)的缓慢结合和定点活性抑制剂,IC50 = 106 nM,对DPP II,DPP III,DPP VIII,DPP IX,FAP几乎没有活性,甚至浓度高达30μM的APP。 了解更多
  16. Teneligliptin hydrobromide

    Catalog No. A15258
    Quick View
    DPP-4 抑制剂
    Teneligliptin hydrobromide是一种新颖,有效且持久的二肽基肽酶-4抑制剂。在体外竞争性抑制人血浆,大鼠血浆和人重组DPP-4,IC50值约为1 nM。 了解更多
  17. UAMC 00039 dihydrochloride

    Catalog No. A16047
    Quick View
    DPP-II 抑制剂
    UAMC 00039 dihydrochloride是二肽基肽酶II(DPP-II)的有效抑制剂(IC50 = 0.48 nM)。展示了DPP-II对DPP-9,DPP-8和DPP-IV的选择性(IC50值分别为78.6、142和165μM)。 了解更多
  18. Talabostat mesylate

    Catalog No. A14080
    Quick View
    DPP-4 抑制剂
    Talabostat mesylate是一种有效的,非选择性的和口服的二肽基肽酶IV(DPP-IV)抑制剂,Ki为0.18 nM。 了解更多
  19. Anagliptin

    Catalog No. A13529
    Quick View
    DPP-4 抑制剂
    Anagliptin是一种有效的选择性DPP-4抑制剂(IC50 = 3.8 nM);DPP-8和DPP-9的效力降低了10倍以上。 了解更多
  20. Alogliptin

    Catalog No. A13571
    Quick View
    DPP-4 抑制剂
    Alogliptin是一种有效的DPP-4选择性抑制剂,IC50 <10 nM,与DPP-8和DPP-9相比具有超过10,000倍的选择性。 了解更多
  21. Sitagliptin

    Catalog No. A14377
    Quick View
    DDP-4 抑制剂
    Sitagliptin是二肽基肽酶-4(DPP-4)抑制剂类别降糖药(抗糖尿病药)。 了解更多
  22. Trelagliptin

    Catalog No. A14293
    Quick View
    DPP-4 抑制剂
    Trelagliptin是一种高度选择性的长效DPP-4抑制剂。 了解更多
  23. Trelagliptin Succinate (SYR-472)

    Catalog No. A13312
    Quick View
    DPP-4 抑制剂
    Trelagliptin Succinate (SYR-472)是一种长效的二肽基肽酶4(DPP-4)抑制剂,正在开发用于治疗2型糖尿病(T2D)。 了解更多
  24. Alogliptin Benzoate

    Catalog No. A13311
    Quick View
    DPP-4 抑制剂
    Alogliptin Benzoate是一种二肽基肽酶4(DPP 4)抑制剂。 了解更多
  25. MK-3102

    Catalog No. A13310
    Quick View
    DPP-4 抑制剂
    Omarigliptin (MK-3102)是一种竞争性的、可逆的DPP-4抑制剂(IC50 = 1.6 nM, Ki = 0.8 nM)。在所有检测的蛋白酶中,包括QPP, FAP, PEP, DPP8和DPP9等,对DPP-4具有高选择性,具有微弱的离子通道活性(IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5)。 了解更多
  26. Vildagliptin

    Catalog No. A12528
    Quick View
    DPP-IV 抑制剂
    Vildagliptin 是一种二肽基肽酶4(CD26)抑制剂。 了解更多
  27. Linagliptin (BI-1356)

    Catalog No. A11224
    Quick View
    DPP-4 抑制剂
    Linagliptin (BI-1356)是DPP-4抑制剂,是一种降解肠降血糖素激素胰高血糖素样肽1(GLP-1)和葡萄糖依赖性促胰岛素多肽(GIP)的酶。 了解更多
  28. Sitagliptin phosphate monohydrate

    Catalog No. A10848
    Quick View
    DDP-4 抑制剂
    Sitagliptin phosphate monohydrate是二肽基肽酶-4(DPP-4)类的抗糖尿病(抗高血糖)药物。 DPP-4酶的抑制作用被认为会增加胰高血糖素样肽1(GLP-1),从而抑制胰高血糖素释放,刺激胰岛素释放并降低血糖。 了解更多
  29. Saxagliptin (BMS-477118)

    Catalog No. A11109
    Quick View
    DPP-4 抑制剂
    Saxagliptin (BMS-477118)是一种新型二肽基肽酶4(DPP-4)抑制剂,IC50为50 nM。 了解更多

29 个项目

每页

设置升序顺序
Rewards