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Autophagy Signaling

Autophagy Signaling

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Resveratrol

Catalog No. A10785
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Resveratrol具有广泛的靶标，包括环氧合酶（COX，IC50 = 1.1μM），脂氧合酶（LOX，IC50 = 2.7μM），激酶，sirtuins和其他蛋白质。它具有抗癌，抗炎，降低血糖和其他有益的心血管作用。了解更多

Product Citations (1)

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- Ha T. Tran, .et al. Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle, PLoS One, 2017, 12(3): e0173373 PMID: 28278187
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Chloroquine Phosphate

Catalog No. A16445
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Chloroquine Phosphate是一种4-氨基喹啉抗疟和抗类风湿药，也可作为ATM活化剂。了解更多

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- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
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Azithromycin Dihydrate

Catalog No. A16421
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Azithromycin Dihydrate是一种酸稳定的口服大环内酯类抗菌药物，在结构上与红霉素有关。了解更多

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Lys05

Catalog No. A16358
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Autophagy 抑制剂

Lys05是有效的溶酶体自噬抑制剂。Lys05是一种先前未描述的二聚氯喹，与HCQ相比，它更有效地积聚在溶酶体中并阻止自噬。了解更多

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Scutellarein

Catalog No. A12234
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Scutellarein是从灯盏细辛中提取的主要活性成分。了解更多

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3-Methyladenine

Catalog No. A11151
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Autophagy/PI3K 抑制剂

3-Methyladenine是III类磷脂酰肌醇3-激酶（PI 3-激酶）的抑制剂。了解更多

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QX77

Catalog No. A13379
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autophagy (CMA) activator

QX77 is a chaperone-mediated autophagy (CMA) activator. 了解更多

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Lys01 trihydrochloride

Catalog No. A21702
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lysosomal autophagy inhibitor

Lys01 trihydrochloride (Lys05) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay. 了解更多

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EN6

Catalog No. A18524
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Autophagy activator

EN6 is a novel covalent autophagy activator, targeting cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. 了解更多

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Aumitin

Catalog No. A18838
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Autophagy inhibitor

Aumitin is an autophagy inhibitor, targeting mitochondrial complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively. 了解更多

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EACC

Catalog No. A19062
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Autophagy inhibitor

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion. 了解更多

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IITZ-01

Catalog No. A20192
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Lysosomotropic autophagy inhibitor

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. 了解更多

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ALLO-1

Catalog No. A18670
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autophagy receptor

ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. 了解更多

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Autophinib

Catalog No. A17241
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Autophagy inhibitor

Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. 了解更多

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ROC-325

Catalog No. A17031
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Autophagy 抑制剂

ROC-325是自噬抑制剂。与现有的自噬抑制剂羟氯喹（HCQ）相比，ROC-325在具有不同遗传背景的12种不同癌细胞系中表现出优异的体外抗癌作用。了解更多

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Monensin sodium

Catalog No. A10603
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ionophore

Monensin sodium是一种离子载体，是自噬在牲畜饲料中的抑制剂。它抑制自噬，干扰自噬体和溶酶体的融合。了解更多

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SMER28

Catalog No. A15867
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Autophagy Activator

SMER28是自噬的小分子增强剂（SMER），在哺乳动物细胞中独立于雷帕霉素诱导自噬。了解更多

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PIK-III

Catalog No. A15868
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Autophagy 抑制剂

PIK-III是βVPS34酶活性的选择性抑制剂。了解更多

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