CNX-2006

目录号: A13755

EGFR 抑制剂

CNX-2006

CNX-2006 Chemical Structure

CAS NO. 1375465-09-0

CNX-2006是一种有效的突变体选择性EGFR抑制剂,在具有激活性EGFR突变的细胞以及具有T790M突变的细胞中具有出色的体外活性。CNX-2006是CO-1686的原型,目前正在I期临床试验中,用于治疗EGFR突变型肺癌。

库存: 现货

规格 价格 数量
10 mg
¥ 1,260.00
25 mg
¥ 2,450.00
50 mg
¥ 4,200.00
100 mg
¥ 7,000.00
10mM * 1mL in DMSO
¥ 1,099.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CNX-2006是一种有效的突变体选择性EGFR抑制剂,在具有激活性EGFR突变的细胞以及具有T790M突变的细胞中具有出色的体外活性。CNX-2006是CO-1686的原型,目前正在I期临床试验中,用于治疗EGFR突变型肺癌。
In vitro DMSO 90 mg/mL (164.97 mM)
Water Insoluble
Ethanol 26 mg/mL (47.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.33 mL 91.65 mL 183.31 mL
0.5 mM 3.67 mL 18.33 mL 36.66 mL
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL

*The above data is based on the productmolecular weight 545.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13755
作用机制 Inhibitor (抑制剂)
M. Wt 545.53
Formula C26H27F4N7O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1375465-09-0
Synonyms CNX2006, CNX 2006
SMILES COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F

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