“Tutalthromycin second gen”的搜索结果
-
progesterone receptor agonist
Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
了解更多
-
Benzodiazepine inverse agonist
DMCM (hydrochloride) is Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
了解更多
-
STING receptor agonist
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs.
了解更多
-
STING receptor agonist
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 nM for human PBMCs.
了解更多
-
LXR agonist
RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
了解更多
-
GPR35/CXCR8 agonist
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
了解更多
-
ERα agonist
Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERα) agonist.
了解更多
-
AhR agonist
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.
了解更多
-
Estrogen receptor β agonist
Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist.
了解更多
-
ERRα inverse agonist
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM).
了解更多
-
STING receptor agonist
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM.
了解更多
-
ERRγ agonist
GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα.
了解更多
- Sen He, .et al. The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors, Toxicology, 2021, May 4;457:152805 PMID: 33961950
-
GPR35/CXCR8 拮抗剂
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
了解更多
-
EP4 激动剂
KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration.
了解更多
-
glucocorticoid receptor agonist
Beclometasone, also known as Beclomethasone, is an anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.
了解更多
-
beta-adrenergic agonist
Nylidrin hydrochloride is a beta-adrenergic agonist. Nylidrin hydrochloride is shown to be an effective inhibitor of IgE-mediated release of histamine from human basophils, and thus can be used as antiallergic agent.
了解更多
-
adrenergic alpha-1 agonist
Midodrine is an ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
了解更多
-
Adrenergic alpha-1 agonist
Midodrine hydrochloride is an ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. It improves clinical outcome of chronic hypotension.
了解更多
-
Na/K ATPase partial agonist
Canrenone is a metabolite of spironolactone, Na/K ATPase partial agonist and aldosterone and androgen receptor antagonist used as a diuretic.
了解更多
-
Glucocorticoid receptor agonist
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.
了解更多
-
Estrogen receptor 激动剂
(R)-Equol是ER&alpha和ER&beta的激动剂,Kis分别为27.4和15.4 nM。
了解更多
- Gao X, .et al. Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol, Toxins (Basel), 2020, Jan 26;12(2) PMID: 31991913
-
Endogenous galanin receptor 激动剂
Galanin (1-30) (human)是具有多种内分泌,代谢和行为作用的内源肽。
了解更多
-
Androgen Receptor 激动剂
Andarine (GTX-007)是研究性的选择性雄激素受体调节剂(SARM)。
了解更多
-
Estrogen/progestogen Receptor 激动剂
Hexestrol是一种致癌的合成雌激素,可抑制微管聚合和带状结构的形成。它是脂质过氧化的抑制剂。
了解更多