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VP3.15 dihydrobromide

Catalog No. A21789
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PDE7/GSK3 inhibitor

VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多

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U18666A

Catalog No. A20195
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cholesterol synthesis/Hedgehog inhibitor

U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. 了解更多

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VP3.15

Catalog No. A18538
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dual PDE7/GSK-3 inhibitor

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多

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Bikinin

Catalog No. A15526
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GSK-3 抑制剂

Bikinin是植物GSK-3/Shaggy-like激酶的有效抑制剂。激活BR受体下游的BR信号传导。了解更多

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MRK 560

Catalog No. A15304
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γ-secretase 抑制剂

MRK 560是一种可用的γ-分泌酶抑制剂，能够显着减少大鼠脑和CSF中的Abeta肽，并证实该大鼠可用于评估γ-分泌酶抑制剂对中枢神经系统Abeta的作用（40）体内水平。了解更多

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TBB

Catalog No. A15257
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CK2 抑制剂

TBB是酪蛋白激酶2（CK2）的高选择性，ATP/GTP竞争性抑制剂，对大鼠肝脏和人重组CK2的IC50分别为0.9和1.6 uM。了解更多

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BC2059

Catalog No. A14381
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beta-catenin inhibitor

BC2059 is an orally bioavailable and potent beta-catenin inhibitor. 了解更多

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- Ji-Hye Jung, .et al. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities, Stem Cells Dev, 2016, Jul 1; 25(13): 1006-1019 PMID: 27188501