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搜索结果：“AZ 960”

“AZ 960”的搜索结果

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AZ-960

Catalog No. A10104
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JAK2抑制剂

AZ-960是一种有效的，选择性的和ATP竞争性的JAK2抑制剂，在体外抑制JAK2激酶的Ki为0.45 nM，并诱导成年T细胞白血病（ATL）细胞的生长停滞和凋亡了解更多

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Tyk2-IN-3

Catalog No. A21982
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Tyk2 pseudokinase inhibitor

Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. 了解更多

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BMS-066

Catalog No. A21972
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IKKβ/Tyk2 pseudokinase inhibitor

BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. 了解更多

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Momelotinib Mesylate

Catalog No. A21658
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JAK1/JAK2 inhibitor

Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. 了解更多

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- Ghazal Nabil, .et al. CD44 Targeted Nanomaterials for Treatment of Triple-Negative Breast Cancer, Cancers (Basel), 2021, Feb 20;13(4):898 PMID: 33672756
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Tyk2-IN-7

Catalog No. A21491
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TYK2 JH2 inhibitor

Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. 了解更多

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JAK-IN-1

Catalog No. A21237
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JAK1/2/3 inhibitor

JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1. 了解更多

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JAK2-IN-4

Catalog No. A12182
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JAK2/JAK3 inhibitor

JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively. 了解更多

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JAK1-IN-4

Catalog No. A18821
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JAK1 抑制剂

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM). 了解更多

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JAK3 covalent inhibitor-1

Catalog No. A18926
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JAK3 covalent 抑制剂

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. 了解更多

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JAK1-IN-7

Catalog No. A19029
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JAK1 抑制剂

JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect. 了解更多

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Tyk2-IN-8

Catalog No. A19052
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TYK2 抑制剂

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis. 了解更多

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WHI-P258

Catalog No. A18317
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JAK3 抑制剂

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 uM. 了解更多

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SD 1008

Catalog No. A15364
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JAK2/STAT3 抑制剂

SD 1008是JAK2/STAT3信号通路抑制剂，可额外抑制Src。注意到SD 1008可诱导表达组成性活性酪氨酸磷酸化STAT3的细胞系凋亡。了解更多

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AZD1480

Catalog No. A10110
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JAK 抑制剂

AZD1480是一种新型有效的小型JAK2抑制剂，IC50为0.26 nM。了解更多

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- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476

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