Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) . 了解更多

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes. 了解更多

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor. 了解更多

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. 了解更多

TMI-1是ADAM17（TACE）和MMP的新型活性双重抑制剂。 了解更多

TAPI-2是TACE，ADAM，ACE分泌酶和其他MMP（金属蛋白酶）的抑制剂。TAPI-2阻止DCC7，APP，TNFα，L-选择素，NOTCH，TGFα，IL-6R9，erbB2/HER2和ACE的释放。该抑制剂已用于组织培养。 了解更多

TAPI-0是TACE（IC50 = 50-100 nM）以及其他基质和膜金属蛋白酶的抑制剂。 了解更多