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GSK137647A

Catalog No. A14542
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FFA4/GPR120 激动剂

GSK137647A是一种选择性FFA4激动剂，对人，小鼠和大鼠FFA4的pEC50分别为6.3、6.2和6.1。了解更多

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KM 11060

Catalog No. A15843
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F508del-CFTR trafficking corrector

KM 11060纠正了F508del-CFTR的运输，增加了质膜上功能性CFTR的量（?75％）并抑制了PDE5的活性。了解更多

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Somatostatin

Catalog No. A13453
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Somatostatin是一种抑制生长激素、胰岛素和胰高血糖素释放的内源性肽。了解更多

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Caffeic Acid Phenethyl Ester

Catalog No. A13698
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NF-κB activation 抑制剂

Caffeic Acid Phenethyl Ester是一种有效且特异性的NF-κB活化抑制剂。了解更多

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4-O-Caffeoylquinic acid

Catalog No. A12036
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4-O-Caffeoylquinic acid也称为隐绿原酸，是绿原酸的异构体，具有抗氧化特性。了解更多

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Fosbretabulin disodium (CA4P)

Catalog No. A13081
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microtubule-targeting agent

Fosbretabulin disodium (CA4P)是来源于非洲灌木柳树(combretum caffrum)的天然芪酚的水溶性磷酸盐衍生物的二钠盐，具有潜在的血管破坏和抗肿瘤活性。了解更多

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Adapalene

Catalog No. A10038
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Adapalene是一类RAR和RXR双重的激动剂，主要用于治疗痤疮。了解更多

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WAY-362450

Catalog No. A11186
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FXR 激动剂

WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
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Caffeic acid

Catalog No. A10171
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Caffeic Acid是一种羟基肉桂酸，是一种天然存在的有机化合物。了解更多

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Tivozanib (AV-951)

Catalog No. A10101
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VEGFR 抑制剂

Tivozanib (AV-951)是一种口服VEGF受体酪氨酸激酶抑制剂，旨在抑制所有三种VEGF受体。了解更多

Product Citations (6)

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- Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
- Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298
- Majid Momeny, .et al. Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells, Sci Rep, 2017, 7: 45954 PMID: 28383032
- Majid Momeny, .et al. Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells, Sci Rep, 2017, 7: 44075 PMID: 28287096
- Nicholas A. Manieri, .et al. Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis, J Clin Invest, 2015, Sep 1; 125(9): 3606-3618 PMID: 26280574
- Usui T, .et al. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells., Acta Physiol (Oxf), 2014, 211, 385-394 PMID: 24612679