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BX-795

Catalog No. A11148
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PDK-1 抑制剂

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。了解更多

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- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
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Bardoxolone methyl (RTA 402)

Catalog No. A11323
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IκB/IKK 抑制剂

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。了解更多

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- Nakamura S, .et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952
- Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
- Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
- Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614
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Bay 65-1942

Catalog No. A11339
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IKKβ 抑制剂

Bay 65-1942是选择性靶向IKKβ激酶活性的ATP竞争性抑制剂。了解更多

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TPCA-1

Catalog No. A11579
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IKK-2 抑制剂

TPCA-1是一种有效且选择性的人IκB激酶2（IKK-2）抑制剂，IKK-2的IC50 = 17.9 nM，而IKK-1的IC50为400nM。了解更多

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- Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
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WS3

Catalog No. A12952
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EBP1 抑制剂

WS3是通过调节Erb3结合蛋白1（EBP1）和IκB激酶途径的β细胞增殖诱导剂。了解更多

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Bay 65-1942 R form

Catalog No. A15018
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IKK 抑制剂?

Bay 65-1942 R form是一种ATP竞争性抑制剂，可选择性靶向IKKβ激酶。了解更多

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LY2409881

Catalog No. A15488
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IKK2 抑制剂

LY2409881是一种有效的选择性IKK2抑制剂，IC50为30 nM，选择性比IKK1和其他常见激酶高10倍以上。了解更多

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AZD3264

Catalog No. A15900
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IKK2 抑制剂?

AZD3264是一种新型的IKK2抑制剂。了解更多

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IKK-3 Inhibitor

Catalog No. A11463
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IKK 抑制剂

IKK-3 Inhibitor是一种有效的，选择性的IKK-ε激酶抑制剂，IC50为40 nM。在IKK-α和IKK-β处无效。了解更多

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INH14

Catalog No. A19119
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IKKα/IKKβ inhibitor

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. 了解更多

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