“Tutalthromycin second gen”的搜索结果
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CYP3A4/5 inhibitor and substrate
Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.
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CYP17 lyase inhibitor
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
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CYP450 dependent inhibitor
Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).
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CYP2C9 inhibitor
Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9.
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CYP17A1/androgen synthesis 抑制剂
TAK-700 Salt (Orteronel Salt)是一种雄激素合成抑制剂。它选择性地抑制在睾丸,肾上腺和前列腺肿瘤组织中表达的酶CYP17A。
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Lipoxygenase 抑制剂
Baicalein是一种类黄酮,最初从黄cut的根中分离出来。Baicalein抑制脂质过氧化 (通过TBARS的产生评估),IC50值为5 ?M。
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Protein kinase 抑制剂
Apigenin是中央苯并二氮杂central受体的配体,其Ki为4μM竞争性抑制氟硝西epa的结合,发挥抗焦虑和轻微的镇静作用。
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Androgen Receptor 拮抗剂
Cyproterone acetate是17-羟孕酮的合成衍生物,可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。
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Naringenin是一种黄烷酮,是一种类黄酮,被认为具有抗氧化剂,自由基清除剂,消炎,碳水化合物代谢促进剂和免疫系统调节剂等对人体健康的生物活性。
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