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Y-26763

Catalog No. A12271
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K+ (KATP) channel activator

Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator. 了解更多

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TRAM-34

Catalog No. A12783
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Potassium Channel Blocker

TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。了解更多

Product Citations (2)

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- Samuel Drinkall, .et al. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation, Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
- Cheong Hoon Seo, .et al. Altered K Ca 3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation, Transl Res, 2021, Apr 24 PMID: 33905948
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NS 309

Catalog No. A11934
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KCa3.1 channel activator

NS 309是小和中电导Ca2+激活的K+通道（KCa2和KCa3.1通道）的正调制器。了解更多

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Nicorandil

Catalog No. A10641
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Kir6 (KATP) channel opener

Nicorandil (SG-75) 钾离子通道活化剂。了解更多

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Glyburide

Catalog No. A10433
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K+ channel and CFTR Cl- channel blocker

Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。了解更多

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Mitiglinide calcium

Catalog No. A11884
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KATP channel 拮抗剂

Mitiglinide calcium是一种降血糖药物，通过关闭胰腺β细胞中的ATP敏感K+通道来刺激胰岛素分泌。了解更多

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Retigabine (Ezogabine)

Catalog No. A11922
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Retigabine是一种新型的抗痉挛剂，在大范围的惊厥模型具有活性。其发挥活性的机制主要是开放神经元的KCNQ2-5电压门控钾离子通道。了解更多

Product Citations (4)

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- Sotatsu Tonomura, .et al. Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats, Mol Brain, 2022, Jul 20;15(1):64 PMID: 35858950
- Vigil FA, .et al. Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, ??M-type??) K+ currents in neurons, J Cereb Blood Flow Metab, 2019, Jul 4:271678X19857818 PMID: 31272312
- Joseph Lombardo, .et al. Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels, J Neurophysiol, 2016, Nov 1; 116(5): 2114-2124 PMID: 27512022
- Sonya M. Bierbower, .et al. Augmentation of M-Type (KCNQ) Potassium Channels as a Novel Strategy to Reduce Stroke-Induced Brain Injury, J Neurosci, 2015, Feb 4; 35(5): 2101-2111 PMID: 25653366