“angiotensin converting enzyme ace”的搜索结果
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Hepatitis B Surface Antigen, adw2 Recombinant
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Adenosine receptor 拮抗剂
Theophylline-7-acetic acid是腺苷受体拮抗剂,是黄嘌呤类化学物质的兴奋剂。
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lysine acetyltransferase KAT6A 抑制剂
WM-1119是赖氨酸乙酰基转移酶KAT6A的高效选择性抑制剂,IC50为0.25 uM。它对KAT6A的活性分别是对KAT5或KAT7的1100倍和250倍。
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tight junction regulator
AT-1001是一个紧密的结点调节器,可将泄漏的结点恢复为常闭状态。
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Retinyl acetate是一种维生素A类似物,可诱导细胞分化并抑制细胞增殖。
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ACE2 抑制剂
MLN-4760是血管紧张素转化(ACE2)抑制剂。在huMNC中,MLN-4760-B检测到63%的ACE2,选择性是ACE的28倍。
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EGFR/HER2 dual 抑制剂
Pyrotinib Racemate是吡罗替尼的外消旋体。吡罗替尼是一种有效的选择性EGFR/HER2双重抑制剂。
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TLR7 激动剂
Gardiquimod TFA是一种化合物,可选择性作用于小鼠和人类形式的Toll样受体7(TLR7)。它起免疫反应调节剂的作用。CAS:1020412-43-4(游离碱)
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5-HT1F receptor 激动剂
LY 344864 racemate是5-HT1F受体激动剂。
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antiviral
BAY41-4109 racemic是BAY41-4109的R-异构体和BAY41-4109的S-异构体的混合物。它抑制HepG2.2.15细胞中的乙型肝炎病毒(HBV)复制,而不影响细胞生长,IC50值为202nM。
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TACE/MMP 抑制剂
TMI-1是ADAM17(TACE)和MMP的新型活性双重抑制剂。
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Quinestrol is a compound used in estrogen replacement therapy.
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D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
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Muscarinic receptor agonist
Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.
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Felbinac is a potent non-steroidal anti-inflammatory agent, used to treat muscle inflammation and arthritis.
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Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate.
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Lawsone is a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye.
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Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor).
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(-)-Borneol is a bicyclic organic compound and a terpene derivative. The hydroxyl group in this compound is placed in an endo position. There are two different enantiomers of borneol. (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
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Oxaceprol is an antirheumatic Agent.
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Lipoic Acid, also known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries.
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muscarinic antagonist
Anisotropine methylbromide is a muscarinic antagonist and antispasmodic. Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents.
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AChE & butyrylcholinesterase inhibitor
Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively).
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Phthalylsulfacetamide is an antibiotic sulfonamide used as a leprostatic agent to treat urinary tract infections.
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Muscarinic antagonist
Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal disorders. It decreases the severity of elastase-induced airspace enlargement and respiratory dysfunction.
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Acetomenaphthone is synthetic vitamin K which is also known as vitmin K4
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JAK3 抑制剂
JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.
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PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.
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MMP inhibitor
Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
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NAD+ Modulator
KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.
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Mcl-1-PUMA interface inhibitor
Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells.
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antibiotic
Cefoxitin Sodium is a semisynthetic cephamycin antibiotic resistant to beta-lactamase. It is derived from Cephamycin C and is highly resistance to β-lactamase inactivation.
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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
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COX-2 抑制剂
Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
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prodrug of paracetamol (PCM)
Propacetamol Hydrochloride is a prodrug of paracetamol (PCM), being effectively used to treat fever and pain.
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Lynestrenol is a synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.
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oncometabolite
Fumaric acid is a fundamental unit of nucleic acids.. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.
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dopamine D1/2 receptor antagonist
Melitracen HCl ia potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function.
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Prostaglandin Receptor inhibitor
Benorilate, also known as Win-11450, is an ester of aspirin and paracetamol with analgesic, antipyretic, and anti-inflammatory activity used in the treatment of rheumatoid diseases. Benorilate has less severe side effects than aspirin.
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pharmaceutic aid
Lanolin, also known as wool wax or wool grease, is a yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid.
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Antiseptic agent
Thymol is a phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge.
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Calcium channel blockers
Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
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Estropipate is a form of estrogen, an estrogen receptor agonist. It has several uses such as: Alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, and treatment of prostate cancer and prevention of osteoporosis.
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CPS1 activator
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.
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Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties
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Acetophenone is used for fragrance in soaps and perfumes, as a flavoring agent in foods, and as a solvent for plastics and resins. It is also a flavouring ingredient used in fruit flavours.
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antibacterial
Sulfacetamide has anti-inflammatory properties when used to treat blepharitis or conjunctivitis (in eye-drop solution). It is believed to work by limiting the presence of folic acid which bacteria need to survive.
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Sodium D-Pantothenate is a vitamin that performs an important role in the oxidation of fats and carbohydrates and certain amino acids. It is also a precursor in the biosynthesis of coenzyme A.
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antibiotics
Midecamycin is a naturally occurring 16-membered macrolide that fits under the category of acetoxy-substituted macrolide antibiotics. In this molecule, an acetoxy group is substituted on the position 9 of the 16-member ring and on position 4 of the terminal sugar.
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antifungal
(L)-alpha-Terpineol is a monoterpene alcohol. It is one of the components responsible for the antifungal activity of Melaleuca alternifolia (tea tree) essential oil. α-Terpineol may be used in the synthesis of α-terpinyl esters of acetic acid and acetic anhydride via lipase-mediated esterification.
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antibiotic
Ceftriaxone sodium is an antibiotic, a third-generation cephalosporin. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positive bacteria and expanded Gram-negative coverage compared to second-generation agents.
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