“bone morphogenetic proteins bmp”的搜索结果
-
E3 ubiquitin ligase ligand
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
了解更多
-
E3 ubiquitin ligase ligand
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
了解更多
-
Bromodomain inhibitor
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
了解更多
-
RGS inhibitor
CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.
了解更多
-
BET inhibitor
(S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.
了解更多
-
cell motility and cell invasion inhibitor
KBU2046 is an oral, highly selective inhibitor of cell motility and cell invasion in vitro. KBU2046 binds chaperone heterocomplexes, selectively alters binding of client proteins that regulate motility, and lacks all of the hallmarks of classical HSP90 inhibitors. KBU2046 inhibits cancer metastasis and prolongs life.
了解更多
-
Acenocoumarol is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of Warfarin. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity, preventing thrombin formation.
了解更多
-
Peretinoin, also known as NIK-333 , orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.
了解更多
-
D2DR inhibitor
Promazine Hydrochloride is a phenothiazine compound and D2DR inhibitor. Promazine Hydrochloride has been employed in studies investigating dopamine-stimulated glycosylation of brain proteins in vitro. It has actions similar to chlorpromazine but with less antipsychotic activity.
了解更多
-
antibacterial
Cefpiramide Sodium is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity. It is the sodium salt form of cefpiramide, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic. Cefpiramide Sodium binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan.
了解更多
-
diuretic
Xipamide is a sulfamoylbenzamide analog of Clopamide. It is a diuretic as well as a saluretic with antihypertensive activity. It is bound to plasma proteins, thus has a delayed onset and prolonged action.
了解更多
-
Mcl-1 inhibitor
Mcl1-IN-1 is a potent and selective inhibitor of the apoptosis regulating proteins Mcl-1.
了解更多
-
14.3.3 proteins 拮抗剂
R18是14.3.3蛋白的拮抗剂(KD≈80 nM)。竞争性地抑制14.3.3-配体相互作用,而无需磷酸化。
了解更多
-
type 1 (SR-BI) inhibitor
BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor.
了解更多
-
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
了解更多
-
Borrelia Afzelii Basic Membrane Protein A Recombinant
了解更多
-
Borrelia Burgdorferi Basic Membrane Protein A Recombinant
了解更多
-
Zerumbone是一种天然单环倍半萜烯,首先从野生姜Z. zerumbet的根茎中分离出来。1它通过佛波酯(IC50 = 140 nM)有效抑制爱泼斯坦-巴尔病毒的激活。
了解更多
-
ENT1 抑制剂
NBMPR是一种核苷类似物,可竞争性抑制平衡的核苷转运蛋白1(大鼠和人的Kd = 0.1-1.0 nM,IC50s = 4.6和3.6 nM)。
了解更多
-
LDN193189 HCl是ldn193189的盐酸盐。LDN193189是一种高效的小分子BMP抑制剂,可抑制BMP I型受体ALK2(IC50:5 nM),ALK3(IC50:30 nM)和ALK6(TGFβ1/ BMP信号转导)以及随后的SMAD磷酸化。
了解更多
- Brandon J.Peiffer, .et al. Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing, Cell Chem Biol, 2019, 26, 1-10
-
BMPS是一种短的巯基和氨基反应性异双功能交联剂。
了解更多
-
Neuroprotectant
Dimebon dihydrochloride是一种非选择性的抗组胺药,具有增强认知能力。
了解更多
-
ALK 抑制剂
LDN193189是一种高效的小分子BMP抑制剂,可抑制BMP I型受体ALK2(IC50=5 nM),ALK3(IC50=30 nM)和ALK6(TGFβ1/BMP信号转导)以及随后的SMAD磷酸化。
了解更多
- Trang Thi Huyen Dang, .et al. BMP10 positively regulates myogenic differentiation in C2C12 myoblasts via the Smad 1/5/8 signaling pathway, Mol Cell Biochem, 2021, May;476(5):2085-2097 PMID: 33517521
- Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo?\epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
- HIROTAKA SOMEYA, .et al. Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells, Int J Mol Med, 2015, May; 35(5): 1169-1178 PMID: 25739055
-
TGF-beta/Smad 抑制剂
GW788388是有效的,口服活性的,选择性的转化生长因子β受体I(TGF-βR1)(激活素受体样激酶5,ALK5)抑制剂,无细胞试验中IC50为18 nM,也抑制TGF-βII型受体和activin II型受体活性,但不抑制BMP II型受体。
了解更多