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产品 151 到 200 共 17506个

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  1. GSK2983559 free acid

    Catalog No. A22272
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    RIP2 kinase inhibitor
    GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. 了解更多
  2. Demethyleneberberine

    Catalog No. A22273
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    mitochondria-targeted antioxidant
    Demethyleneberberine is a natural mitochondria-targeted antioxidant. 了解更多
  3. AUNP-12

    Catalog No. A22274
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    peptide antagonist
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. 了解更多
  4. Sodium oxamate

    Catalog No. A22275
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    LDH inhibitor
    Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH?A. 了解更多
  5. Motixafortide

    Catalog No. A22276
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    CXCR4 antagonist
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ??1 nM. 了解更多
  6. iFSP1

    Catalog No. A22277
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    glutathione-independent inhibitor
    iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. 了解更多
  7. GMB475

    Catalog No. A22279
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    BCR-ABL1 tyrosine kinase degrader
    GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. 了解更多
  8. Citronellol

    Catalog No. A22280
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    used in perfumes and insect repellents
    Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. Citronellol can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. 了解更多
  9. L-2-Hydroxyglutaric acid disodium

    Catalog No. A22281
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    epigenetic modifier
    L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. 了解更多
  10. Ellagic acid (hydrate)

    Catalog No. A22282
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    ATP-competitive CK2 inhibitor
    Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. 了解更多
  11. JX06

    Catalog No. A22283
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    PDK inhibitor
    JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. 了解更多
  12. Tomatidine hydrochloride

    Catalog No. A22284
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    anti-inflammatory agent
    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. 了解更多
  13. MLS000532223

    Catalog No. A22285
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    Rho family GTPases inhibitor
    MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. 了解更多
  14. Amarogentin

    Catalog No. A22286
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    bitter taste receptor TAS2R1 agonist
    Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. 了解更多
  15. Urolithin B

    Catalog No. A22287
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    regulator of skeletal muscle mass
    Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B is also a regulator of skeletal muscle mass. 了解更多
  16. EB-3D

    Catalog No. A22288
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    choline kinase α (ChoKα) inhibitor
    EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. 了解更多
  17. HA-100 dihydrochloride

    Catalog No. A22289
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    PKs inhibitor
    HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 ?M, respectively). 了解更多
  18. Pyruvic acid

    Catalog No. A22290
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    organic chemical intermediate
    Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. 了解更多
  19. Palmitoleic acid

    Catalog No. A22291
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    composition of fatty acid
    Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats. 了解更多
  20. 3-Hydroxyanthranilic acid

    Catalog No. A22292
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    immunomodulatory agent
    3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators. 了解更多
  21. Tomatine

    Catalog No. A22293
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    precipitating agent
    Tomatine is an glycoalkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. 了解更多
  22. Acetosyringone

    Catalog No. A22294
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    anti-inflammatory agent
    Acetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. 了解更多
  23. SC-43

    Catalog No. A22295
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    SHP-1 (PTPN6) agonist
    SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. 了解更多
  24. AC1903

    Catalog No. A22296
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    TRPC5 inhibitor
    AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. 了解更多
  25. Dorzagliatin

    Catalog No. A22297
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    GK activator
    Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes. 了解更多
  26. Lavendustin B

    Catalog No. A22298
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    GLUT1 inhibitor
    Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 ?M. Lavendustin B is also a weak inhibitor of tyrosine kinases. 了解更多
  27. GDC046

    Catalog No. A22299
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    TYK2 inhibitor
    GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor of TYK2 with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively. 了解更多
  28. BD750

    Catalog No. A22300
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    JAK3/STAT5 inhibitor
    BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively. 了解更多
  29. BioE-1115

    Catalog No. A22301
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    PASK inhibitor
    BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM. 了解更多
  30. Homosalate

    Catalog No. A22302
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    chemical UV filter
    Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage. 了解更多
  31. Ribociclib hydrochloride

    Catalog No. A22303
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    CDK4/6 inhibitor
    Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, 了解更多
  32. Gallein

    Catalog No. A22304
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    Gβγ subunit signalling inhibitor
    Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent. 了解更多
  33. SRX3207

    Catalog No. A22305
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    Syk/PI3K inhibitor
    SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression. 了解更多
  34. BDTX-189

    Catalog No. A22306
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    Anticancer agent
    BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多
  35. LDN-193189 2HCl

    Catalog No. A22307
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    BMP signaling inhibitor
    LDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. 了解更多
  36. BpV(HOpic)

    Catalog No. A22308
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    PTEN inhibitor
    BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity. 了解更多
  37. 2-Phospho-L-ascorbic acid trisodium

    Catalog No. A22309
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    antioxidant
    2-Phospho-L-ascorbic acid trisodium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. 了解更多
  38. Ferulic acid sodium

    Catalog No. A22310
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    FGFR1 inhibitor
    Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. 了解更多
  39. BL-918

    Catalog No. A22311
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    ULK1 activator
    BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC50 of 24.14 nM. 了解更多
  40. L-Quebrachitol

    Catalog No. A22312
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    natural product
    L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. 了解更多
  41. Loureirin A

    Catalog No. A22313
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    flavonoid
    Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. 了解更多
  42. Kaempferol 3-neohesperidoside

    Catalog No. A22314
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    flavonoid
    Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle. 了解更多
  43. Higenamine

    Catalog No. A22315
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    β2-AR agonist
    Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. 了解更多
  44. Alflutinib

    Catalog No. A22316
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    EGFR inhibitor
    Alflutinib is an EGFR inhibitor that targets both EGFR activating mutations and T790M, thus leading to tumor growth inhibition. 了解更多
  45. MCP110

    Catalog No. A22317
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    inhibitor of Ras/Raf-1 interaction
    MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors. 了解更多
  46. BO-264

    Catalog No. A22318
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    TACC3 inhibitor
    BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. 了解更多
  47. DCLK1-IN-1

    Catalog No. A22319
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    chemical probe
    DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. 了解更多
  48. IM156

    Catalog No. A22320
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    AMPK activator
    IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. 了解更多
  49. ABTL-0812

    Catalog No. A22321
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    antineoplastic agent
    ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity. 了解更多
  50. Remibrutinib

    Catalog No. A22322
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    BTK inhibitor
    Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. 了解更多

产品 151 到 200 共 17506个

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