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Cell Metabolism

Cell Metabolism

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Leriglitazone

Catalog No. A18636
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PPAR gamma agonist

Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. 了解更多

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Chiglitazar

Catalog No. A12701
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PPARα/γ dual agonist

Chiglitazar is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. 了解更多

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GW0742

Catalog No. A14958
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PPAR 激动剂

GW0742是PPARδ的选择性激动剂，EC50值为1.1 nM。了解更多

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GW1929

Catalog No. A15099
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PPAR 激动剂

GW1929是一种合成的过氧化物酶体增殖物激活受体-γ（PPARγ）激动剂，对人和人的IC50为6.2 nM和13 nM。了解更多

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Balaglitazone

Catalog No. A15013
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PPAR-γ partial 激动剂

Balaglitazone是PPAR-γ（γ）的新型局部激动剂。了解更多

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BMS-687453

Catalog No. A15836
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PPAR 激动剂

BMS-687453是一种有效的选择性过氧化物酶体增殖物激活受体（PPAR）α激动剂，对人PPARα的EC（50）为10 nM，在PPAR-GAL4反式激活试验中，选择性是对人PPARgamma的410倍。了解更多

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Aleglitazar

Catalog No. A12492
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PPAR-α/γ 激动剂

Aleglitazar是一种新型的双重PPAR-α/γ激动剂，IC50为2.8 nM/4.6 nM。了解更多

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Elafibranor

Catalog No. A15454
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PPAR 激动剂

Elafibranor是过氧化物酶体增殖物激活的受体-α和-δ的激动剂，可诱导非酒精性脂肪性肝炎消退，而不会使纤维化恶化。了解更多

Product Citations (6)

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- Joost Boeckmans, .et al. Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery, Cells, 2022, 11(5), 893 PMID: 35269515
- Tomasz Kostrzewski, .et al. Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system, Commun Biol, 2021, 4: 1080 PMID: 34526653
- Joost Boeckmans, .et al. Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH, MethodsX, 2020, 7: 101068 PMID: 33024711
- Joost Boeckmans, .et al. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists, Cell Biol Toxicol, 2020, Jul 1 PMID: 32613381
- Joost Boeckmans, .et al. Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor, Data in Brief, 2019, June 3 PMID: 31294056
- Boeckmans J, .et al. Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH, Pharmacol Res, 2019, Apr 24. pii: S1043-6618(18)31850-4 PMID: 31028903
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CDDO-Im

Catalog No. A16308
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PPARγ 激动剂

CDDO-Im是一种新型的合成三萜，在体外和体内均比其母体化合物CDDO更有效。PPARγ激动剂。了解更多

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5-Aminosalicylic Acid

Catalog No. A10570
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PPARγ agonist

5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 了解更多

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Pioglitazone hydrochloride

Catalog No. A16670
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PPARγ agonist

Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. 了解更多

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Fonadelpar

Catalog No. A20848
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PPARδ agonist

Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. 了解更多

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Tesaglitazar

Catalog No. A20891
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PPAR alpha/gamma agonist

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively. 了解更多

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Arhalofenate

Catalog No. A21135
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PPARγ agonist

Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. 了解更多

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Indeglitazar

Catalog No. A21148
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PPAR agonist

Indeglitazar is an orally available peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). 了解更多

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Inolitazone

Catalog No. A21180
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PPARγ agonist

Inolitazone a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition. 了解更多

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