Potassium Channels

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  1. Vernakalant HCl

    Catalog No. A15275
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    Ion channel blocker
    Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂,可以以2至5 mg/kg的剂量终止人的急性心房纤颤(AF),并且与现有药物相比,对房颤的选择性更高。在抗心律不齐的治疗中。 了解更多
  2. Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride是钾通道阻滞剂。抑制起搏器电流(If)和超极化激活的阳离子电流(Ih)。通过灭活GSK-3β来防止血清和钾缺乏的小脑颗粒神经元中caspase-3的激活和神经元凋亡。 了解更多
  3. 4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. 了解更多
  4. ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多
  5. JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. 了解更多
  6. TAK-438 (vonoprazan)

    Catalog No. A11239
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    potassium-competitive acid Blocker
    TAK-438 (vonoprazan)是一种新型的钾竞争酸阻滞剂。 了解更多
  7. Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。 了解更多
  8. PAP-1 (5-(4-Phenoxybutoxy)psoralen)

    Catalog No. A11521
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    Kv1.3 blocker
    PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的,选择性的,口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3,并通过优先绑定到通道的 C 型灭活状态来起作用。 了解更多
  9. TRAM-34

    Catalog No. A12783
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    Potassium Channel Blocker
    TRAM-34是中等电导Ca2+激活的K+通道(KCa3.1)(Kd = 20 nM)的高度选择性阻滞剂。在KV,BKCa,KCa2,Na+,CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。 了解更多
  10. E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker?
    E-4031 dihydrochloride是KV11.1(hERG)通道的选择性阻滞剂;禁止快速延迟整流器K+电流(IKr)。 了解更多
  11. Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
    Glyburide (Glibenclamide) 是一种抗糖尿病化合物,是一类磺脲类药物。 了解更多

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