Protein Tyrosine Kinases

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  1. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR 抑制剂
    Pazopanib (GW-786034)是VEGFR-1,VEGFR-2,VEGFR-3,PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂,可阻止肿瘤生长并抑制血管生成。 了解更多
  2. Dovitinib (TKI-258)

    Catalog No. A11411
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  3. Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
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    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。 了解更多
  4. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 抑制剂
    Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  5. Tandutinib (MLN518)

    Catalog No. A10887
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    FLT3 抑制剂
    Tandutinib (MLN518)是一种有效的FLT3抑制剂,c-KIT和PDGF受体酪氨酸激酶的自磷酸化,从而抑制细胞增殖并诱导细胞凋亡。 了解更多
  6. BLZ945

    Catalog No. A15540
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    CSF1R 抑制剂
    BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率,同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。 了解更多
  7. AZD7507

    Catalog No. A16886
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    CSF-1R 抑制剂
    AZD7507是一种有效的选择性CSF-1R抑制剂(32 nM细胞活性),AZD7507被认为是一种很有前途的化合物,因为它保留了AZ683所需的效能和口服药代动力学特性。 了解更多
  8. PLX5622

    Catalog No. A18888
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    CSF1R inhibitor
    PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. 了解更多
  9. JTE-952

    Catalog No. A18391
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    CSF-1R 抑制剂
    TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. 了解更多

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