Endothelin Receptors

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  1. Aprocitentan

    Catalog No. A21999
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    dual ETA/ETB antagonist
    Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. 了解更多
  2. Macitentan (n-butyl analogue)

    Catalog No. A21845
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    endothelin ETA and ETB receptor antagonist
    Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). 了解更多
  3. Darusentan

    Catalog No. A21280
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    endothelin A (ETA) receptor antagonist
    Darusentan is a selective endothelin A (ETA) receptor antagonist. 了解更多
  4. Tezosentan

    Catalog No. A21118
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    endothelin (ET) receptor antagonist
    Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. 了解更多
  5. Sparsentan

    Catalog No. A20879
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    angiotensin II and endothelin A receptor antagonist
    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. 了解更多
  6. Endothelin Mordulator 1

    Catalog No. A13040
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    endothelin receptor modulator
    Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders. 了解更多
  7. PD-159020

    Catalog No. A13499
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    ETA/ETB antagonist
    PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively. 了解更多
  8. RO462005

    Catalog No. A13216
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    endothelin receptor 激动剂
    RO462005是内皮素受体选择性激动剂。 了解更多
  9. Macitentan

    Catalog No. A11492
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    Endothelin receptor 拮抗剂
    Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂,IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。 了解更多
  10. IRL-2500

    Catalog No. A13638
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    ETBR 拮抗剂
    IRL-2500是一种有效的选择性ETBR拮抗剂。它显示了对ETB受体的一些选择性(对于ETB和ETA受体,IC50值分别为1.3和94 nM)。 了解更多
  11. Atrasentan HCl

    Catalog No. A15007
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    Endothelin 拮抗剂 receptor
    Atrasentan hydrochloride是一种开发用于治疗前列腺癌的内皮素拮抗剂受体(IC50 = 0.0551 nM,ETA)。 了解更多
  12. Endothelin-2, human

    Catalog No. A14894
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    Endothelin-2, human是人的内源肽,主要存在于肾脏和肠中。对ETA和ETB内皮素受体具有相似的选择性。 了解更多
  13. BQ-123

    Catalog No. A15912
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    ETA receptor 拮抗剂
    BQ-123是一种选择性内皮素A受体(ETA)拮抗剂,IC50为7.3 nM。 了解更多
  14. Bosentan Hydrate

    Catalog No. A14944
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    ET-A and ET-B 拮抗剂
    Bosentan Hydrate是ET-A和ET-B的内皮素(ET)受体拮抗剂,Ki分别为4.7 nM和95 nM。 了解更多
  15. Atrasentan

    Catalog No. A13779
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    ETA 拮抗剂
    Atrasentan是一种实验药物,正在研究中,用于治疗各种类型的癌症,包括非小细胞肺癌。它是对A型亚型(ETA)有选择性的内皮素受体拮抗剂,对ETA的IC50为0.0551 nM。 了解更多
  16. BQ-788

    Catalog No. A14369
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    ETBR 拮抗剂
    BQ-788 sodium salt是一种选择性ETBR(内皮素受体B)拮抗剂。 了解更多
  17. Sitaxsentan sodium (TBC-11251)

    Catalog No. A11564
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    ETA receptor 拮抗剂
    Sitaxsentan sodium (TBC-11251)是一种选择性内皮素受体A拮抗剂,IC50和Ki分别为1.4 nM和0.43 nM。 了解更多
  18. Avosentan (SPP301)

    Catalog No. A11301
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    Endothelin 拮抗剂
    Avosentan (SPP301)是一种强效且高度选择性的ETA受体阻滞剂。 了解更多
  19. Ambrisentan (BSF 208075)

    Catalog No. A11291
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    EndothelinA receptor 拮抗剂
    Ambrisentan (BSF 208075)充当内皮素受体拮抗剂,对A型内皮素受体(ETA)具有选择性。 了解更多
  20. Bosentan

    Catalog No. A11091
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    ETAR/ETBR 抑制剂
    Bosentan是内皮素-1(ET-A)和内皮素B(ET-B)受体的竞争性拮抗剂。 了解更多
  21. Zibotentan (ZD4054)

    Catalog No. A11006
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    ETA-receptor 拮抗剂
    Zibotentan (ZD4054)是一种有效且特异性的ETA受体(内皮素A受体)拮抗剂(IC50 = 21 nM),对ETB没有抑制活性。 了解更多

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