Endothelin Receptors

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Catalog No. Product Name Application Product Information
A11492 SALE

Macitentan

Endothelin receptor 拮抗剂
Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
A13216

RO462005

endothelin receptor 激动剂
RO462005 is an endothelin receptor selective agonist.
A15912

BQ-123

ETA receptor 拮抗剂
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
A15007

Atrasentan HCl

Endothelin 拮抗剂 receptor
Atrasentan hydrochloride is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
A14894

Endothelin-2, human

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Endothelin-2, human, endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
A13779

Atrasentan

ETA 拮抗剂
Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is an endothelin receptor antagonist selective for subtype A (ETA).
A14369

BQ-788

ETBR 拮抗剂
BQ-788 sodium salt is a selective ETBR (Endothelin receptor B ) antagonist.
A11564 SALE

Sitaxsentan sodium (TBC-11251)

ETA receptor 拮抗剂
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.
A11301

Avosentan (SPP301)

Endothelin 拮抗剂
Avosentan (SPP301) is a potent and highly selective ETA receptor blocker.
A11291 SALE

Ambrisentan (BSF 208075)

EndothelinA receptor 拮抗剂
Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
A11091 SALE

Bosentan

ETAR/ETBR 抑制剂
Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
A11006

Zibotentan (ZD4054)

ETA-receptor 拮抗剂
Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
A14944

Bosentan Hydrate

ET-A and ET-B 拮抗剂
Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

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