“ab fubinaca”的搜索结果

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  1. Tianeptine sodium

    Catalog No. A10931
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    5-HT Receptor 激动剂
    Tianeptine钠是体内和体外的选择性5-羟色胺再摄取促进剂(SSRE)。 了解更多
  2. WIN 55,212-2 mesylate

    Catalog No. A11932
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    CB receptor 激动剂
    WIN 55,212-2 mesylate是一种有效的cannabinoid receptor激动剂,在神经性疼痛的大鼠模型中具有有效的镇痛作用。它通过受体介导的信号激活p42和p44 MAP激酶。 了解更多
  3. Aripiprazole (Abilify)

    Catalog No. A11801
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    5-HT1A receptor 激动剂
    Aripiprazole (Abilify)是人5-HT1A受体部分激动剂,Ki为4.2 nM。 了解更多
  4. Cabergoline

    Catalog No. A13844
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    Dopamine receptor 激动剂
    Cabergoline是一种有效的多巴胺D2受体激动剂。 了解更多
  5. Tedalinab

    Catalog No. A14189
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    CB2 receptor 激动剂
    Tedalinab (GRC-10693)是开发用于治疗骨关节炎和神经性疼痛的药物,它可作为有效的选择性大麻素CB2受体激动剂。与相关的CB1受体相比,它对CB2的选择性为4700x,具有很高的口服生物利用度,并在早期临床试验中显示出令人鼓舞的安全性结果以及有效的镇痛和抗炎作用。 了解更多
  6. Guanabenz acetate

    Catalog No. A13635
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    2A-AR adrenergic 激动剂
    Guanabenz acetate是a2A-AR肾上腺素能激动剂和IGRS(咪唑啉I2结合位点)选择性配体。 了解更多
  7. Rimonabant hydrochloride

    Catalog No. A11548
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    CB1 receptor inverse 激动剂
    Rimonabant hydrochloride是CB1受体反向激动剂。 了解更多
  8. Trimebutine maleate

    Catalog No. A18115
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    ?- opioid receptor agonist
    Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. 了解更多
  9. VCE-004.8

    Catalog No. A18549
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    PPARγ and CB2 receptor dual agonist
    VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多
  10. KAG-308

    Catalog No. A18389
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    EP4 激动剂
    KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. 了解更多
  11. Kynurenic acid

    Catalog No. A16581
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    GPR35/CXCR8 拮抗剂
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. 了解更多
  12. Semaglutide

    Catalog No. A18908
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    GLP-1 receptor agonist
    Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes. 了解更多
  13. SB756050

    Catalog No. A12759
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    TGR5 agonist
    SB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes. 了解更多
  14. CB2R-IN-1

    Catalog No. A12306
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    cannabinoid CB2 receptor inverse agonist
    CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse agonist with a Ki of 0.9 nM. 了解更多
  15. AB-MECA

    Catalog No. A12189
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    A3 adenosine receptor agonist
    AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors. 了解更多
  16. LY2922470

    Catalog No. A12181
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    GPR40 agonist
    LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. 了解更多
  17. GPR35 agonist 1

    Catalog No. A12462
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    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多
  18. β3-AR agonist 1

    Catalog No. A12777
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    β3-adrenergic receptor agonist
    β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). 了解更多
  19. Kynurenic acid sodium

    Catalog No. A20000
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    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多
  20. Taranabant

    Catalog No. A11578
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    CB1 receptor inverse agonist
    Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro. 了解更多
  21. Cenerimod

    Catalog No. A20913
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    S1P1 agonist
    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. 了解更多
  22. Cutamesine

    Catalog No. A21152
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    sigma 1 receptor agonist
    Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(??1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4??1.9 nM); 100-fold less affinity for the sigma 2 receptor. 了解更多
  23. AM-1638

    Catalog No. A21505
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    GPR40/FFA1 full agonist
    AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. 了解更多
  24. Taranabant ((1R,2R)stereoisomer)

    Catalog No. A21705
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    CB1 receptor inverse agonist
    Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. 了解更多
  25. AM-4668

    Catalog No. A21778
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    GPR40 agonist
    AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively. 了解更多
  26. Vilazodone D8

    Catalog No. A21876
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    SSR inhibitor / 5-HT1A receptor partial agonist
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多
  27. Aripiprazole (D8)

    Catalog No. A22004
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    human 5-HT1A receptor partial agonist
    Aripiprazole D8 (OPC-14597 D8) is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. 了解更多

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