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AMG 837 sodium salt
Catalog No. A21793 GPR40 agonistAMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. 了解更多 -
diABZI STING agonist-1 trihydrochloride
Catalog No. A21694 STING receptor agonistdiABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs. 了解更多 -
diABZI STING agonist-1
Catalog No. A21688 STING receptor agonistdiABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 nM for human PBMCs. 了解更多 -
Nelotanserin
Catalog No. A21506 5-HT2A inverse agonistNelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. 了解更多 -
Varenicline Tartrate
Catalog No. A11618 nicotinic receptor partial agonistVarenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does. 了解更多 -
STING agonist-4
Catalog No. A19074 STING receptor agonistSTING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. 了解更多 -
Talsaclidine
Catalog No. A18571 muscarinic agonistTalsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes. 了解更多 -
FzM1.8
Catalog No. A18760 FZD4 agonistFzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. 了解更多 -
Taltirelin
Catalog No. A18250 TRH-R agonistTaltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). 了解更多 -
Baclofen
Catalog No. A18248 GABA agonistBaclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多 -
Lusutrombopag
Catalog No. A18089 thrombopoietin (TPO) receptor agonistLusutrombopag, also known as S-888711, is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. 了解更多
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