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Defactinib hydrochloride

Catalog No. A22003
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FAK inhibitor

Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多

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Defactinib

Catalog No. A21958
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FAK inhibitor

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. 了解更多

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E-3810

Catalog No. A15073
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VEGFR/FGFR 抑制剂

E-3810是一种有效且选择性的VEGF和FGF受体双重抑制剂，对VEGFR-1，VEGFR-2，VEGFR-3，FGFR-1和VEGF的IC50值分别为7nM，25nM，10nM，17.5nM和82.5nM。FGFR-2。了解更多

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PF-04554878 (Defactinib)

Catalog No. A11929
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FAK 抑制剂

PF-04554878 (Defactinib)是一种新型FAK激酶抑制剂，可降低胰腺神经内分泌肿瘤细胞的生长并诱导其凋亡。了解更多

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- Shalana O'Brien, .et al. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics, Oncotarget., 2014, Sep; 5(17): 7945-7959. PMID: 25277206
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XL184 free base (Cabozantinib)

Catalog No. A10996
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VEGFR 抑制剂

XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。了解更多

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- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358