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搜索结果：“jwh 250”

“jwh 250”的搜索结果

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ON-013100

Catalog No. A16191
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cell cycle 抑制剂

ON-013100是细胞周期抑制剂，可能可用于治疗套细胞淋巴瘤。了解更多

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SPL-B

Catalog No. A16085
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TACC3 抑制剂

SPL-B是转化酸性卷曲螺旋蛋白（TACC3）的口服活性抑制剂，可选择性抑制卵巢癌细胞中中心体微管的成核，而不会影响正常细胞中的纺锤体组装。了解更多

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CGS 35066

Catalog No. A16033
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ECE 抑制剂

CGS 35066是有效的内皮素转化酶（ECE）抑制剂。了解更多

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PF-3644022

Catalog No. A11282
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MK2 抑制剂

PF-3644022是一种有效的选择性促分裂原活化蛋白激酶（MAPK）活化蛋白激酶2（MK2）抑制剂（Ki = 3 nM）。了解更多

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LHW090-A7

Catalog No. A13885
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NEP 抑制剂

LHW090-A7是中性内肽酶（NEP）的抑制剂，NEP是负责脑啡肽代谢失活的酶。了解更多

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AZ7371

Catalog No. A15817
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DprE1 抑制剂

AZ7371是新型的非共价DprE1抑制剂。了解更多

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Ro 48-8071

Catalog No. A14203
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OSC 抑制剂

Ro 48-8071是OSC（氧化角鲨烯环化酶；IC50 = 6.5 nM）的抑制剂，具有低密度脂蛋白（LDL）胆固醇降低活性。了解更多

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Nisoxetine hydrochloride

Catalog No. A13418
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Noradrenalin re-uptake 抑制剂

Nisoxetine hydrochloride是去甲肾上腺素转运蛋白的选择性强抑制剂，对一系列其他神经递质受体几乎没有或没有亲和力。Nisoxetine hydrochloride是SLC6A2的抑制剂。了解更多

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TNP-470

Catalog No. A14014
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MetAP-2 抑制剂

TNP 470是富马西林的类似物，在体外显示有效的抗血管生成活性。已显示出抑制MetAP-2（甲硫氨酸氨基肽酶II型）的作用。了解更多

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GZ-793A

Catalog No. A13569
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VMAT2 抑制剂

GZ-793A是囊泡单胺转运蛋白2 (VMAT2)的选择性抑制剂，它将单胺神经递质从细胞胞质溶胶转运到突触小泡中。了解更多

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AB05831

Catalog No. A14384
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beta-hexosaminidase 抑制剂

AB05831是一种高效且特异的β-己糖胺酶抑制剂。了解更多

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GSK-650394

Catalog No. A13309
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SGK1 抑制剂

GSK 650394是一种糖皮质激素和血清调节激酶1（SGK1）抑制剂，对LNCaP前列腺癌细胞系表现出抗增殖特性。了解更多

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N6022

Catalog No. A13046
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GSNOR 抑制剂

N6022是S-亚硝基谷胱甘肽还原酶（GSNOR）的有效，特异性和完全可逆抑制剂，IC50为8 nM，Ki为2.5 nM。了解更多

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PTC-209

Catalog No. A13826
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BMI-1 抑制剂

PTC-209是一种新型的有效选择性BMI-1抑制剂，靶向BMI-1自我更新机制，IC50为?0.5μM。了解更多

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NKY 80

Catalog No. A13586
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Adenylyl Cyclase 抑制剂

NKY 80是腺苷酸环化酶（AC）的抑制剂。与AC3和AC2相比，对AC5的亲和力更大（IC50值分别为8.3μM，132μM和1.7 mM）。了解更多

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ME-143

Catalog No. A13101
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tNOX 抑制剂

ME-143是三苯二酚的衍生物，是一种高效的泛效抗癌药物。了解更多

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Tolrestat

Catalog No. A13083
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aldose reductase 抑制剂

Tolrestat是醛糖还原酶抑制剂[1],被批准用于控制某些糖尿病并发症。了解更多

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Quarfloxin (CX-3543)

Catalog No. A12380
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rRNA biogenesis 抑制剂

Quarfloxin (CX-3543)是一种具有抗肿瘤活性的氟喹诺酮衍生物。quarfloxin破坏核蛋白和核糖体dna (rdna)模板中g-四链体dna结构之间的相互作用，这是在癌细胞中过度表达的rrna生物发生的关键相互作用；这种g-四链体dna的破坏:异常rrna生物发生中的蛋白质相互作用可能导致核糖体合成和肿瘤细胞凋亡的抑制。了解更多

Product Citations (4)

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- Janne J. M. van Schie, .et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion, Nat Commun, 2020, 11: 4287 PMID: 32855419
- Yue Sheng, .et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs, Blood, 2020, Aug 21 PMID: 32822452
- Hald øH, .et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma, Oncogene, 2018, Dec 12 PMID: 30542116
- Louise E. Kerry, .et al. Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis, PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991
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Diclofensine

Catalog No. A10305
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Monoamine reuptake 抑制剂

Diclofensine (Ro 8-4650)用作三重单胺再摄取抑制剂，主要抑制多巴胺和去甲肾上腺素的再摄取。了解更多

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Avibactam

Catalog No. A11299
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β-lactamase 抑制剂

Avibactam是一种共价，可逆的非β-内酰胺β-内酰胺酶抑制剂。了解更多

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- Moonsuk Bae, .et al. In Vitro Activities of Ceftazidime-Avibactam and Aztreonam-Avibactam at Different Inoculum Sizes of Extended-Spectrum β-Lactam-Resistant Enterobacterales Blood Isolates, Antibiotics (Basel), 2021, Dec 5;10(12):1492 PMID: 34943704
- Taeeun Kim, .et al. In Vitro Activities and Inoculum Effects of Ceftazidime-Avibactam and Aztreonam-Avibactam against Carbapenem-Resistant Enterobacterales Isolates from South Korea, Antibiotics (Basel), 2020, Dec 15;9(12):912 PMID: 33334045
- Annelien Everaert, .et al. Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species, Antimicrob Resist Infect Control, 2016, 5: 44 PMID: 27895902
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BCH

Catalog No. A13370
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LAT1 抑制剂

BCH是L型氨基酸转运蛋白LAT1的抑制剂。通过激活KB，Saos2和C6癌细胞系中的半胱氨酸蛋白酶抑制生长并诱导凋亡。了解更多

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Apramycin Sulfate

Catalog No. A13243
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protein synthesis 抑制剂

Apramycin Sulfate是一种广谱的氨基环醇抗生素，是由链霉菌链霉菌属菌株产生的内布拉霉素复合物的成分。了解更多

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Azomycin (2-Nitroimidazole)

Catalog No. A10099
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Protein synthesis 抑制剂

Azomycin(2-Nitroimidazole)是由肠系诺卡氏菌产生的一种抗菌抗生素，对需氧革兰氏阳性和革兰氏阴性细菌具有活性。了解更多

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