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搜索结果：“ADM Hydrochloride”

“ADM Hydrochloride”的搜索结果

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Amsacrine hydrochloride

Catalog No. A17707
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antineoplastic agent

Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. 了解更多

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Niraparib hydrochloride

Catalog No. A18018
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PARP1 and PARP2 inhibitor

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多

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Resminostat hydrochloride

Catalog No. A15220
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HDAC 抑制剂

Resminostat hydrochloride是HDAC1/3/6的有效抑制剂（IC50 = 43-72 nM）；对HDAC8的效力较低，IC50为877 nM。了解更多

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Givinostat hydrochloride

Catalog No. A21487
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HDAC inhibitor

Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. 了解更多

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Pirarubicin Hydrochloride

Catalog No. A18037
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topoisomerase II inhibitor

Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors. 了解更多

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Voreloxin Hydrochloride

Catalog No. A15280
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Topoisomerase 抑制剂

Voreloxin hydrochloride是一种小分子，是具有抗肿瘤活性的萘啶类似物；Topo II抑制剂。了解更多

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PJ 34 hydrochloride

Catalog No. A12665
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PARP 抑制剂

PJ 34 hydrochloride是聚（ADP-核糖）聚合酶（PARP）（EC50 = 20 nM）的有效抑制剂。了解更多

Product Citations (2)

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- Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
- Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
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Epirubicin HCl

Catalog No. A10345
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Topoisomerase II 抑制剂

Epirubicin HCl是一种可透过细胞的蒽环类抗肿瘤抗生素。它用于抑制拓扑异构酶II和DNA解旋酶活性。了解更多

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PIK-75 hydrochloride

Catalog No. A10729
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PI3K 抑制剂

PIK-75是一种p110α抑制剂，IC50值为5.8nM。在p110γ和p110β的效果较差，IC50值为0.076 ?M和1.3 ?M。了解更多

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- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
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Veliparib dihydrochloride

Catalog No. A21356
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PARP inhibitor

Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多

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Nolatrexed Dihydrochloride

Catalog No. A13261
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Thymidylate synthase 抑制剂

Nolatrexed Dihydrochloride是一种抗叶酸胸苷酸合酶抑制剂。了解更多

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Sarafloxacin HCl

Catalog No. A11659
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Topoisomerase 抑制剂

Sarafloxacin hydrochloride是氟喹诺酮类抗菌剂。抑制细菌DNA促旋酶（拓扑异构酶）。了解更多

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