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搜索结果：“AZ 960”

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Cyclo(RGDyK)

Catalog No. A21819
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αVβ3 integrin inhibitor

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. 了解更多

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Carotegrast

Catalog No. A21997
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α4 integrin receptor inhibitor

Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. 了解更多

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Tasidotin hydrochloride

Catalog No. A21944
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microtubule assembly and microtubule dynamics inhibitor

Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics. 了解更多

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DM1-Sme

Catalog No. A15960
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maytansinoid microtubular 抑制剂

DM1-SMe是一种有效的美登木素生物碱微管抑制剂，是未结合的DM1，是与硫代甲烷混合的二硫化物，用于封端巯基。了解更多

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MPI-0479605

Catalog No. A14290
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Mps1 抑制剂

MPI-0479605是有丝分裂激酶Mps1的ATP竞争性和选择性抑制剂。了解更多

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Cabazitaxel

Catalog No. A11831
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Microtubule Associated 抑制剂

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。了解更多

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- Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
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Nocodazole

Catalog No. A13219
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microtubule 抑制剂

Nocodazole是微管抑制剂；抑制有丝分裂。也抑制自噬体-溶酶体融合。了解更多

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Ixabepilone

Catalog No. A11449
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microtubule 抑制剂

Ixabepilone是epothilone B类似物。了解更多

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- Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006
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AZ 3146

Catalog No. A11170
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Mps1 抑制剂

AZ 3146是一种有效的选择性单极纺锤体1 (Mps1) 激酶抑制剂 (IC50 = 35 nM) 。它会干扰染色体对齐并覆盖纺锤体装配检查点，还抑制将Mad1，Mad2和着丝粒蛋白E（CENP-E）募集到动植物。了解更多

Product Citations (4)

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- Ryuzaburo Yuki, .et al. The tyrosine kinase v-Src modifies cytotoxicities of anticancer drugs targeting cell division, J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
- Yamagishi A, .et al. Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation, Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
- Kakihana A, .et al. Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint, FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
- Suzuki M, .et al. Effect of MPS1 Inhibition on Genotoxic Stress Responses in Murine Tumour Cells, Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789