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YO-01027

Catalog No. A11174
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γ-secretase 抑制剂

YO-01027是一种二肽γ-secretase抑制剂，作用于APPL和Notch分裂，无细胞试验中IC50分别为2.6 nM和2.9 nM，一种抗阿尔茨海默氏病药物。了解更多

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AZD3839

Catalog No. A12825
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BACE1 抑制剂

AZD3839是人类BACE1的有效选择性抑制剂，Ki为26.1 nM。了解更多

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Lanabecestat

Catalog No. A12282
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BACE1 inhibitor

Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多

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BMS-906024

Catalog No. A21172
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gamma secretase inhibitor

BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. 了解更多

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β-Secretase Inhibitor IV

Catalog No. A21346
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BACE-1 inhibitor

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. 了解更多

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AZD3839 free base

Catalog No. A21606
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BACE1 inhibitor

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多

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