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Apilimod

Catalog No. A13794
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IL-12/IL-23 inhibitor

Apilimod is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?Cstimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. 了解更多

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Cerdulatinib

Catalog No. A14210
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multi-targeted tyrosine kinase 抑制剂

Cerdulatinib (PRT-062070)是多靶点酪氨酸激酶抑制剂，对JAK1/JAK2/JAK3/TYK2和Syk的IC50分别为12 nM/6 nM/8 nM/0.5 nM和32 nM。了解更多

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Monomethyl auristatin E

Catalog No. A12954
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Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。了解更多

Product Citations (1)

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- Sochaj-Gregorczyk AM, .et al. A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines, J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324
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JNJ-28312141

Catalog No. A12687
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CSF1R 抑制剂

JNJ-28312141是一种口服活性CSF1R抑制剂（Colony-stimulating factor-1受体，CRF1R），也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达，是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。了解更多

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