“betaine hydrochloride”的搜索结果
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nAChR modulator
Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity.
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GABAA receptors agonist
Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects.
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α4β2 nAChR partial agonist
Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist.
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NMDA receptor antagonist
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
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GlyT1 inhibitor
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.
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mAChR antagonist
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.
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GABAA receptor partial agonist
CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity.
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CaMK-II 抑制剂
KN-92 hydrochloride是KN-93的阴性对照。
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nAChR 抑制剂
EVP-6124 hydrochloride是一种新型的α7神经元烟碱型乙酰胆碱受体(nAChRs)的部分激动剂。EVP-6124对α7nAChRs具有选择性,并且不激活或抑制异源α4β2nAChRs。
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mAChR agonist
Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.
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nAChR antagonist
Mecamylamine hydrochloride is a nAChR antagonist previously used to treat hypertension. It displays a wide variety of activities, including reducing depression-like behaviors in subjects with Tourette's syndrome and improving rates of smoking cessation.
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Antispasmodic Agent
Pitofenone Hydrochloride是抗痉化合物。它是乙酰胆碱酯酶活性的有效抑制剂。
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AChE 抑制剂
Acotiamide hydrochloride trihydrate是一种在日本获准用于治疗餐后饱胀,上腹胀气和功能性消化不良引起的早饱的药物。
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M1 激动剂
Cevimeline hydrochloride hemihydrate是一种新型毒蕈碱受体激动剂,是干燥综合征干燥症的候选治疗药物。
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α-adrenergic (AR) 拮抗剂/CaM 抑制剂
Phenoxybenzamine hydrochloride是一种细胞可渗透的,非特异性的,不可逆的α-肾上腺素(AR)拮抗剂,也可作为CaM抑制剂。
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Gabapentin Hydrochloride是一种加巴类似物。
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P2X7 allosteric modulator
GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
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nAChR 激动剂
GTS-21 dihydrochloride (DMBX-A)是一种选择性的α7烟碱乙酰胆碱受体激动剂,最近已被确定为一种有希望的炎症治疗方法。
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- P Yamini, .et al. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease, Pharmacol Biochem Behav, 2022, Jun;217:173402 PMID: 35533773
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COX 抑制剂/histamine H1 receptor 激动剂
Fexofenadine Hydrochloride是一种抗组胺药,可抑制Cox-1,Cox-2,并且是组胺H1受体激动剂,IC50为246 nM。
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AChR抑制剂
Adiphenine Hydrochloride是烟碱受体抑制剂,IC50为15μM,用作解痉药物。
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Neuroprotectant
Dimebon dihydrochloride是一种非选择性的抗组胺药,具有增强认知能力。
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NMDA receptor ion channel 拮抗剂
ARL-15896是新型的N-甲基-D-天冬氨酸受体离子通道拮抗剂。
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- Robert A. Volkmann, .et al. MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit, PLoS One, 2016, 11(2): e0148129 PMID: 26829109
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AChE 抑制剂
Desoxypeganine hydrochloride是一种AChE(乙酰胆碱酯酶)抑制剂,已用于治疗阿尔茨海默氏痴呆症。
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Ticlopidine是一种二磷酸腺苷(ADP)受体抑制剂。它通过阻断ADP受体来改变血小板膜的功能,从而抑制血小板聚集。这防止了糖蛋白IIb/IIIa的构象变化,从而使血小板与血纤蛋白原结合。
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P2Y12 拮抗剂
Prasugrel Hydrochloride是噻吩并吡啶ADP受体(P2Y12)拮抗剂,用于减少血栓性心血管事件。
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Anxiolytic anticonvulsant
Etifoxine hydrochloride是培养的神经元中GABAA受体功能的增强剂。
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P2X7 receptor 拮抗剂
A 438079 hydrochloride是一种竞争性P2X7受体拮抗剂(抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9)。
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- Zhihua Yi, .et al. Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain, Front Pharmacol, 2018, 9: 593 PMID: 29950989
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cholinesterase 抑制剂
Donepezil hydrochloride是一种中枢可逆的乙酰胆碱酯酶抑制剂。
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Muscarinic receptor antagonist
Biperiden HCl是毒蕈碱受体拮抗剂,对M1亚型表现出一定的选择性。
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GABA uptake 抑制剂
SKF 89976A HCl是一种有效的GABA吸收抑制剂,hGAT-1,rGAT-2,hGAT-3和hBGT-1的IC50分别为0.13、550、944和7210μM。
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AChE and BChE 抑制剂
Tacrine hydrochloride hydrate是乙酰(AChE)和丁酰胆碱酯酶(BChE)的抑制剂,IC50分别为31 nM和25.6 nM。
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GABA reuptake 抑制剂
Tiagabine hydrochloride是一种抗惊厥药。该药物还用于治疗惊恐症,还有其他一些抗惊厥药。
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GABA uptake 抑制剂
Guvacine hydrochloride可抑制GABA的摄取(hGABA T-1,rGABA T-2,hGABA T-3和hBGT-1的IC50值分别为14、58、119和1870 uM)。
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NMDA receptor 拮抗剂
Memantine hydrochloride是nmda受体的拮抗剂,与离子通道位点结合。它还是CYP2B6和CYP2D6抑制剂,作用于重组CYP2B6和CYP2D6,Ki分别为0.51 nM和94.9 μM。它被用于治疗帕金森综合征。
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