“Ligand-gated Ion Channels”的搜索结果
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HCV RNA replication inhibitor
Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
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HCV RNA replication inhibitor
Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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HCV RNA replication inhibitor
PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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HCV replication inhibitor
R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM).
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HCV NS5B polymerase inhibitor
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
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HCV replication 抑制剂
RO-9187是复制系统中HCV病毒复制的有效抑制剂(IC(50)= 171+/-12 nM;CC(50)> 1 mM)。
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HCV replication 抑制剂
Anguizole是一种抑制HCV复制并改变NS4B亚细胞分布的小分子。
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- Choi M, .et al. A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B-s dimerization/multimerization as well as its interaction with NS5A, Virus Genes., 2013, Dec;47(3):395-407 PMID: 23868571