“leukotriene receptor”的搜索结果
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AMPA/kainate receptors agonist
(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.
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L-type calcium antagonist
Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors.
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AMPA (CP-AMPA) receptors antagonist
Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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Ca2+-dependent blocker
TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.
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AMPA receptors potentiator
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
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CP-AMPA receptors antagonist
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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TRPV1 receptor
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
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AMPA receptor positive allosteric modulator
PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.
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AMPA receptor antagonist
SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist.
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nuclear export receptor CRM1 inhibitor
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
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AMPA receptors positive allosteric modulator
CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor.
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AMPA receptors allosteric modulator
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
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hERG potassium channel inhibitor
Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor.
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TRPM8 agonist
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
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TRPC6 inhibitor
TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM.
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TRPM8 antagonist
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist.
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TRPV1 receptor 拮抗剂
SB-366791是新颖,有效且选择性的肉桂酰胺TRPV1拮抗剂。
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AMPA/kainate receptor 拮抗剂
Talampanel是AMPA受体的非竞争性拮抗剂,具有抗癫痫活性。
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TRPV1 receptor 拮抗剂
A-889425是选择性TRPV1受体拮抗剂。A-889425阻断TRPV1通道,IC50为335 nM(大鼠)和34 nM(人)。
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vanilloid receptor 激动剂
Resiniferatoxin是从大戟属(Euphorbia)属的一些植物中分离出的辣椒素的天然类似物(货号92350),包括E. resinifera。
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- Thieu X. Phan, .et al. TRPV1 in arteries enables a rapid myogenic tone, bioRxiv, 2021, February 27
- Thieu X Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure, J Physiol, 2020, Sep 17 PMID: 32944976
- Thieu X. Phan, .et al. TRPV1 expressed throughout the arterial circulation regulates vasoconstriction, bioRxiv, 2020, February 04
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AMPA receptor modulator
Farampator是一种AMPA受体正调节剂,它可以改善短期记忆,但会损害情景记忆。
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AMPA Receptor Blocker
IEM 1754 Dihydrobromide是AMPA受体的电压依赖性明渠阻断剂。
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NMDA receptor 拮抗剂
DNQX是一种非N-甲基-D-天冬氨酸(非NMDA)受体复合物拮抗剂。
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AMPA Receptor 拮抗剂
NBQX是一种有效,选择性和竞争性的AMPA受体拮抗剂。
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AMPA Receptor 抑制剂
Aniracetam是一种安非他命,属于消旋体化学类别的促智药,据称比吡乙酰胺更有效。
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NMDA receptor 拮抗剂
Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。
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