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搜索结果：“jwh 249”

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Methoxy-PEPy

Catalog No. A21899
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mGlu5 receptor antagonist

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. 了解更多

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Tipelukast

Catalog No. A21249
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leukotriene receptor antagonist

Tipelukast (KCA 757) is a sulfidopeptide leukotriene receptor antagonist, an orally bioavailable anti-inflammatory agent and used for the treatment of asthma. 了解更多

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Toreforant

Catalog No. A21058
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histamine H4 receptor (H4R) antagonist

Toreforant is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM. 了解更多

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OP-3633

Catalog No. A18468
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Glucocorticoid Receptor Antagonist

OP-3633 is a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (IC50 = 29 nM). 了解更多

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JNJ-10229570

Catalog No. A16876
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MC1R and MC5R 拮抗剂

JNJ-10229570是一种新型MC1R和MC5R拮抗剂，用于治疗原代人皮脂细胞。其抑制125I-NDP-α-MSH和人类细胞中MC1R和MC5R结合的IC50值分别为 270 nM 和 200 nM。了解更多

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SB225002

Catalog No. A14209
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CXCR2 拮抗剂

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。了解更多

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SB 334867

Catalog No. A12786
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OX1 receptor 拮抗剂

SB 334867是一种选择性的非肽orexin OX1受体拮抗剂。对于分别表达人OX1和OX2受体的CHO细胞中的细胞内Ca2 +释放抑制，pKb值为7.2和<5。体内全身给药后，阻断orexin-A诱导的美容和进食。了解更多

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- Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
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Tolterodine tartrate (Detrol LA)

Catalog No. A10937
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muscarinic receptor 拮抗剂

Tolterodine tartrate (Detrol LA)是毒蕈碱受体拮抗剂。了解更多

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