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￥ 0.00 “Ligand-gated Ion Channels”的搜索结果
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RV01
Catalog No. A19104 ALDH2 inhibitorRV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 decreases iNOS expression, with anti-neuroinflammatory activity. 了解更多 -
Keap1?CNrf2-IN-1
Catalog No. A19097 PPI inhibitorKeap1?CNrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. 了解更多 -
Vanin-1-IN-1
Catalog No. A19095 Vanin-1 enzyme inhibitorVanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation. 了解更多 -
AAPK-25
Catalog No. A19085 Aurora/PLK dual 抑制剂AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. 了解更多 -
Melagatran
Catalog No. A19083 Thrombin inhibitorMelagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. 了解更多 -
Syncytial Virus Inhibitor-1
Catalog No. A19053 RSV fusion inhibitorSyncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively. 了解更多 -
SEC inhibitor KL-2
Catalog No. A19043 SEC inhibitorSEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. 了解更多 -
Soluflazine
Catalog No. A18968 nucleoside transport inhibitorSoluflazine is a nucleoside transport inhibitor with anticonvulsant action. Soluflazine can be used as an antiepileptic agent. 了解更多 -
PKC-theta inhibitor 1
Catalog No. A18966 PKCθ inhibitorPKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. 了解更多 -
PTC299
Catalog No. A18935 VEGFA inhibitorPTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis. 了解更多 -
CA inhibitor 1
Catalog No. A18928 HIV capsid inhibitorCA inhibitor 1 (GS-6207 analog) is a potent HIV capsid inhibitor for HIV inhibition. 了解更多 -
3-Hydroxydecanoic acid
Catalog No. A18903 mitotic progression inhibitor3-Hydroxycapric acid is an inhibitor for mitotic progression. 了解更多 -
HSP27 inhibitor J2
Catalog No. A18874 HSP27 inhibitorHSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. 了解更多 -
LYPLAL1-IN-1
Catalog No. A18852 LYPLAL1 inhibitorLYPLAL1-IN-1 (Compound 11) is an selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (LYPLAL1) with an IC50 of 0.006 μM. LYPLAL1-IN-1 increases glucose production. 了解更多 -
p32 Inhibitor M36
Catalog No. A18846 p32 mitochondrial protein inhibitorp32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1. 了解更多 -
TVB-3664
Catalog No. A18829 FASN inhibitorTVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression. 了解更多 -
Rodatristat
Catalog No. A18820 TPH1/TPH2 inhibitorRodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. 了解更多 -
Asymmetric dimethylarginine
Catalog No. A18704 NOS inhibitorAsymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. 了解更多 -
MARK4 inhibitor 1
Catalog No. A18695 (MARK4 inhibitorMARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. 了解更多 -
Mutated EGFR-IN-2
Catalog No. A18565 EGFR 抑制剂Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=??1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity. 了解更多 -
MC-Sq-Cit-PAB-Dolastatin10
Catalog No. A18518 tubulin polymerization inhibitorMC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB. 了解更多 -
Heptasaccharide Glc4Xyl3
Catalog No. A18495 Endo-xyloglucanases inhibitorHeptasaccharide Glc4Xyl3, a covalent inhibitor of endo-xyloglucanases, is used for the identification and analysis of diverse xyloglucan-active enzymes in nature. 了解更多 -
STAT3-IN-3
Catalog No. A18479 STAT3 inhibitorSTAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). 了解更多 -
MD2-TLR4-IN-1
Catalog No. A18452 MD2-TLR4 inhibitorMD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多 -
SKF-34288 hydrochloride
Catalog No. A18451 PEPCK inhibitorSKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor. SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway. 了解更多 -
PD-1-IN-22
Catalog No. A18434 PD-1/PD-L1 interaction inhibitorPD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM. 了解更多 -
IDH1 Inhibitor 2
Catalog No. A18420 IDH1 inhibitorDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. 了解更多 -
Ebselen
Catalog No. A20834 HIV-1 capsid CTD dimerization inhibitorEbselen (SPI-1005) is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase (IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity . 了解更多 -
Desoxyrhaponticin
Catalog No. A20832 FAS inhibitorDesoxyrhaponticin is a stilbene glycoside from the Tibetan nutritional food Rheum tanguticum Maxim. Desoxyrhaponticin is a Fatty acid synthase (FAS) inhibitor, and has apoptotic effect on human cancer cells. 了解更多 -
Enzaplatovir
Catalog No. A20830 RSV fusion protein inhibitorEnzaplatovir is an inhibitor of Respiratory Syncytial Virus (RSV). It can be used as a viral fusion protein inhibitor. 了解更多 -
Nafamostat hydrochloride
Catalog No. A20828 serine protease inhibitorNafamostat hydrochloride is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多 -
Nafamostat
Catalog No. A20827 serine protease inhibitorNafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. 了解更多 -
PD-1-IN-17
Catalog No. A12157 programmed cell death-1 (PD-1) inhibitorPD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM. 了解更多 -
Mebendazole
Catalog No. A16606 Hedgehog inhibitorMebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. 了解更多
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