“abl”的搜索结果

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  1. PP121

    Catalog No. A11207
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    PI3K 抑制剂
    PP121是一种作用于PDGFR,Hck,mTOR,VEGFR2,Src和Abl的多靶点抑制剂,IC50分别为2 nM,8 nM,10 nM,12 nM,14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。 了解更多
  2. AZ32

    Catalog No. A16814
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    ATM 抑制剂
    AZ32是ATM激酶的特异性抑制剂,对小鼠具有良好的BBB渗透性,ATM酶的IC50值<0.0062 uM。它对ATR有足够的选择性,并且具有较高的细胞通透性。 了解更多
  3. VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
  4. VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多
  5. PI3Kdelta inhibitor 1

    Catalog No. A19249
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    PI3Kδ inhibitor
    PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM. 了解更多
  6. GDC-0077

    Catalog No. A19494
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    PI3Kα inhibitor
    GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). 了解更多
  7. ON 146040

    Catalog No. A16266
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    dual PI3K and BCR-ABL 抑制剂
    ON 146040是第一个靶向STAT3和STAT5途径的PI3K和BCR-ABL双重抑制剂;抑制PI3Kα/δ同工型,IC50为14/20 nM。 了解更多

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