“angiotensin converting enzyme ace”的搜索结果
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Androgen Receptor 拮抗剂
Cyproterone acetate是17-羟孕酮的合成衍生物,可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。
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HMG-CoA Reductase 抑制剂
Clinofibrate是一种脂质清除剂,似乎可以改变脂质代谢,减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)(羟甲基戊二酰辅酶A还原酶),IC50为0.47 mM。
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Bazedoxifene Acetate是第三代选择性雌激素受体调节剂(SERM)。
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- Renu Sudhakar, .et al. Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation, Microbiol Spectr, 2022, Jun 29;10(3) PMID: 35616371
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Prednisolone是合成的糖皮质激素,是皮质醇的衍生物,用于治疗各种炎症和自身免疫性疾病。
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RAAS 抑制剂
Enalaprilat dihydrate是依那普利的活性代谢产物。它是第一种含二羧酸盐的ACE抑制剂,IC50为1.2 nM。
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GnRH 拮抗剂
Abarelix acetate是一种合成的肽促性腺激素释放激素受体(GnRH)拮抗剂。
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GnRH 拮抗剂
Degarelix acetate是促性腺激素释放激素(GnRH)受体拮抗剂。
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Megestrol Acetate是具有抗肿瘤特性的孕酮衍生物。
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GHRP-6 Acetate是一种生长激素释放肽。
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LTA4 hydrolase 抑制剂
Captopril disulfide是LTA4水解酶的可逆竞争性抑制剂(IC50 = 11 M)。Captopril已被证明是血管紧张素转化酶-1(ACE1)的一种,而不是ACE2(IC50 = 22 nM)。
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Acetyl Angiotensinogen (1-14), porcine血管紧张素原基因编码的蛋白质被称为血管紧张素原或血管紧张素原的前体。
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GnRH 激动剂
Leuprolide Acetate是GnRH类似物;醋酸亮丙瑞林在垂体GnRH受体上起激动剂的作用。
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Renin 抑制剂
VTP-27999 2,2,2-trifluoroacetate是一种烷基胺肾素抑制剂。VTP-27999可用于高血压和末梢器官疾病。
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GnRH 激动剂
Triptorelin Acetate是一种促性腺激素释放激素激动剂(GnRH激动剂),用作乙酸盐或pamoate盐。
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GnRH 激动剂
Goserelin Acetate是具有抗肿瘤活性的促黄体激素释放激素(LHRH)的合成十肽类似物。
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progesterone receptor 激动剂
Medroxyprogesterone acetate是一种孕激素,是人激素黄体酮的合成变异体,也是一种强效的黄体酮受体激动剂。
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- Xijian Wang, .et al. Anxiety determination by antibody-conjugated nanoparticles on an interdigitated electrode sensor, 3 Biotech, 2020, Sep;10(9):377 PMID: 32802719
- Xiucui Bao, .et al. Coordinated Dispersion and Aggregation of Gold Nanorod in Aptamer-Mediated Gestational Hypertension Analysis, J Anal Methods Chem, 2019, Article ID 5676159
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Chlormadinone acetate是一种甾体孕激素,具有额外的抗雄激素和促性腺激素作用,通常与口服避孕药联合使用。
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ACE2 抑制剂
MLN-4760是血管紧张素转化(ACE2)抑制剂。在huMNC中,MLN-4760-B检测到63%的ACE2,选择性是ACE的28倍。
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GnRH/LHRH receptor agonist
Leuprorelin is a Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.
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GnRH agonist
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH.
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GnRH antagonist
Cetrorelix acetate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The IC50 of 1.21 nM.
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glucocorticoid
Betamethasone acibutate, derives from Betamethasone, is an acetate ester. Betamethasone acibutate is a glucocorticoid.
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Estrogen receptor degrader
Elacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.
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glucocorticoid receptor agonist
Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist.
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estrogen receptor degrader
GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases.
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progesterone receptor agonist
Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors.
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synthetic GnRH agonist
Alarelin acetate is a synthetic GnRH agonist.
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progesterone receptor modulator
Ulipristal (acetate) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
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angiotensin AT2 receptor 拮抗剂
PD 123319 ditrifluoroacetate是一种有效的,选择性的非肽血管紧张素AT2受体拮抗剂。大鼠肾上腺组织和大脑的IC50值分别为34和210 nM。
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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
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Angiotensin II receptor 拮抗剂
Tasosartan是一种血管紧张素II受体拮抗剂。
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angiotensin receptor-neprilysin 抑制剂
LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂(ARNi),用于治疗高血压和心力衰竭。
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angiotensin II receptor 拮抗剂
BIBS39是一种非肽血管紧张素II(AII)受体拮抗剂,可从其特异性结合位点置换[125I] AII,其AII亚型(AT1)受体和K(i)的K(i)值为29+/-7 nM。)AII亚型2(AT2)受体的480+/-110 nM)值。
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angiotensin II receptor type 1 拮抗剂
Azilsartan medoxomil是一种口服给药的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
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RAAS 抑制剂
Benazepril hydrochloride是一种非肽血管紧张素转化酶(ACE)抑制剂。降低自发性高血压大鼠的血压和心肌肥大。
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Captopril是一种血管紧张素转换酶(ACE)抑制剂,用于治疗高血压和某些类型的充血性心力衰竭。
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Moexipril hydrochloride是一种有效的口服活性非巯基血管紧张素转换酶抑制剂(ACE),可作用于高血压和充血性心力衰竭。
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ACE 抑制剂
Cilazapril monohydrate是哒嗪血管紧张素转换酶抑制剂(ACE抑制剂),用于治疗高血压和充血性心力衰竭。
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ACE 抑制剂
Temocapril是一种ACE抑制剂。
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Perindopril Butylamine是一种血管紧张素转化酶(ACE)抑制剂。
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Imidapril (Tanatril)是血管紧张素转化酶(ACE)的抑制剂。
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ACE 抑制剂
Zofenopril calcium是一种血管紧张素转化酶ACE抑制剂。
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- Tomas Jasenovec, .et al. Angiotensin System Modulations in Spontaneously Hypertensive Rats and Consequences on Erythrocyte Properties; Action of MLN-4760 and Zofenopril, Biomedicines, 2021, Dec 14;9(12):1902 PMID: 34944718
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Enkephalin-degrading and ACE 抑制剂
Spinorphin是一种内源性因子,对脑啡肽降解酶具有抑制作用。
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Angiotensin AT1 receptor antagonist
SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.
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angiotensin II receptor antagonist
Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
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angiotensin II receptor type 1 antagonist
Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
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angiotensin II and endothelin A receptor antagonist
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
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Angiotensin-II subtype 2 receptor(AT2 R) agonist
CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.
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angiotensin II receptor antagonist
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.
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angiotensin II type 1 receptor antagonist
Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
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angiotensin-(1-7) receptor agonist
AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM.
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