“Akt Inhibitor”的搜索结果

产品 301 到 350 共 5382个

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  1. FDI-6

    Catalog No. A19514
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    FOXM1 inhibitor
    FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. 了解更多
  2. BET-IN-4

    Catalog No. A19516
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    BRD4 inhibitor
    BET-IN-4 is a potent BET bromodomain protein (BRD4) inhibitor, with an IC50 of ?? 1 μM. 了解更多
  3. JFD00244

    Catalog No. A19517
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    SIRT2 inhibitor
    JFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect. 了解更多
  4. MKC8866

    Catalog No. A19523
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    IRE1 RNase inhibitor
    MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29?μM in human vitro. 了解更多
  5. Pralsetinib

    Catalog No. A19526
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    RET inhibitor
    Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. 了解更多
  6. BMS-816336

    Catalog No. A19528
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    11β-HSD1 inhibitor
    BMS-816336 is a novel, potent and orally bioavailable inhibitor against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM. 了解更多
  7. GSTO1-IN-1

    Catalog No. A19530
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    GSTO1 inhibitor
    GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM. 了解更多
  8. BRD 4354

    Catalog No. A19532
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    HDAC5/HDAC9 inhibitor
    BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. 了解更多
  9. ERK2 IN-1

    Catalog No. A19533
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    ERK2 inhibitor
    ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM. 了解更多
  10. EHMT2-IN-2

    Catalog No. A19534
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    EHMT inhibitor
    EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2. Used in the research of blood disease or cancer. 了解更多
  11. Salicyl-AMS

    Catalog No. A19535
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    mycobactin biosynthesis inhibitor
    Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit M. tuberculosis growth in vitro under iron-limited conditions. 了解更多
  12. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

    Catalog No. A19540
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    protease inhibitor
    N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death. 了解更多
  13. TAS6417

    Catalog No. A19541
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    EGFR inhibitor
    TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM. 了解更多
  14. GlyRS-IN-1

    Catalog No. A19543
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    GlyRS inhibitor
    GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria. 了解更多
  15. KDM4D-IN-1

    Catalog No. A19545
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    KDM4D inhibitor
    KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. 了解更多
  16. Corin

    Catalog No. A19548
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    LSD1 inhibitor
    Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. 了解更多
  17. DS88790512

    Catalog No. A19551
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    TRPC6 inhibitor
    DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM. 了解更多
  18. ALX-1393

    Catalog No. A19557
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    GlyT2 inhibitor
    ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model. 了解更多
  19. KH7

    Catalog No. A19559
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    sAC-specific inhibitor
    KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. 了解更多
  20. BAY-678 racemate

    Catalog No. A19564
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    HNE inhibitor
    BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). 了解更多
  21. SMS2-IN-2

    Catalog No. A19568
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    SMS2 inhibitor
    SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity. 了解更多
  22. RAD51-IN-2

    Catalog No. A19570
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    RAD51 inhibitor
    RAD51-IN-2 (compound example 67A) is a RAD51 inhibitor extracted from patent WO2019/051465A1. 了解更多
  23. IRAK4-IN-1

    Catalog No. A19572
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    IRAK4 inhibitor
    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. 了解更多
  24. IDH889

    Catalog No. A19578
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    IDH1 inhibitor
    IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). 了解更多
  25. SNIPER(BRD)-1

    Catalog No. A19579
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    SNIPER inhibitor
    SNIPER(BRD4)-1 is a specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein eraser (SNIPER) which acts as a protein degradation inducer of bromodomain-containing protein 4 (BRD4). 了解更多
  26. Leu-AMS

    Catalog No. A19580
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    LRS inhibitor
    Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. 了解更多
  27. PI3Kδ-IN-1

    Catalog No. A19582
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    PI3Kδ inhibitor
    PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. 了解更多
  28. Capzimin

    Catalog No. A19585
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    proteasome isopeptidase Rpn11 inhibitor
    Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor. 了解更多
  29. PF-06795071

    Catalog No. A19592
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    covalent MAGL inhibitor
    PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM. 了解更多
  30. Cirsiliol

    Catalog No. A19602
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    5-lipoxygenase inhibitor
    Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand. 了解更多
  31. 5,6,7-Trimethoxyflavone

    Catalog No. A19612
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    p38-α MAPK inhibitor
    5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera. 了解更多
  32. FT895

    Catalog No. A19615
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    HDAC11 inhibitor
    FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. 了解更多
  33. KP-457

    Catalog No. A19622
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    ADAM17 inhibitor
    KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively. 了解更多
  34. ABT-702 dihydrochloride

    Catalog No. A19624
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    AK inhibitor
    ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM). 了解更多
  35. PDE5-IN-2

    Catalog No. A19625
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    PDE5 inhibitor
    PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity. 了解更多
  36. Melinamide

    Catalog No. A19631
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    cholesterol absorption inhibitor
    Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM. 了解更多
  37. inS3-54A18

    Catalog No. A19639
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    STAT3 inhibitor
    inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. 了解更多
  38. CBS9106

    Catalog No. A19643
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    CRM1 inhibitor
    CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. 了解更多
  39. NAcM-OPT

    Catalog No. A19646
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    DCN1 inhibitor
    NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction. 了解更多
  40. IDO-IN-9

    Catalog No. A19647
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    IDO inhibitor
    IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 6. 了解更多
  41. GNE-131

    Catalog No. A19649
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    NaV1.7 inhibitor
    GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. 了解更多
  42. SHIP2-IN-1

    Catalog No. A19650
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    SHIP2 inhibitor
    SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer??s disease. 了解更多
  43. Y06137

    Catalog No. A19656
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    BET inhibitor
    Y06137 is a potent and selective BET inhibitor for treatment of castration-resistant prostate cancer (CRPC). Y06137 binds to the BRD4(1) bromodomain with a Kd of 81 nM. 了解更多
  44. Asciminib

    Catalog No. A19658
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    Bcr-Abl inhibitor
    Asciminib (ABL001) is a potent and selective allosteric Bcr-Abl inhibitor; inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. 了解更多
  45. Y06036

    Catalog No. A19665
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    BET inhibitor
    Y06036 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM. Antitumor activity. 了解更多
  46. ACY-957

    Catalog No. A19666
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    HDAC1 /HDAC2 inhibitor
    ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. 了解更多
  47. CA-5f

    Catalog No. A19668
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    macroautophagy/autophagy inhibitor
    CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. 了解更多
  48. NCT-505

    Catalog No. A19669
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    ALDH1A1 inhibitor
    NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM). 了解更多
  49. RP-54745

    Catalog No. A19681
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    interleukin inhibitor
    RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. 了解更多
  50. S 2101

    Catalog No. A19683
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    LSD1 inhibitor
    S 2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s. 了解更多

产品 301 到 350 共 5382个

每页
页面:
  1. 5
  2. 6
  3. 7
  4. 8
  5. 9

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