“Ligand-gated Ion Channel”的搜索结果
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Calcium Channel antagonist
Fantofarone is a highly potent Calcium Channel antagonist.
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Calcium channel proteins inhibitor
Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
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Na+ channel blocker
Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain.
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KCNQ1 potassium channel activator
ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
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T-type Ca2+ channel antagonist
TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist.
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TRPP3 channel inhibitor
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
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dual T-type and L-type calcium channel blocker
Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
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Calcium channel blocker
Levamlodipine besylate ((S)-Amlodipine besylate) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.
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potassium channel inhibitor
VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM.
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T-type Ca2+ channel antagonist
TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease.
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hERG potassium channel inhibitor
Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor.
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Sodium Channel Nav1.7 inhibitor
Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor.
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L-type Ca2+ channel agonist
(S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM).
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calcium channel inhibitor
Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM).
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non-voltage dependent calcium channel blocker
Carboxyamidotriazole (L 651582) is a blocker of non-voltage dependent calcium channel.
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dual T-type and L-type calcium channel blocker
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).
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calcium channel blocker
Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels.
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voltage-gated sodium channel Nav1.7 inhibitor
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.
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TRP Channel blocker
SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
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calcium channel blocker
Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties.
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T-type calcium channel inhibitor
MK-8998 (compound 33) is a potent and selective inhibitor of the T-type calcium channel.
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calcium channel blocker
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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T-type Ca2+ channel blocker
ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
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SK channel inhibitor
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 ?M.
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Calcium channel blocker
Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
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T-type Ca2+ channel blocker
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
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neuroprotective agent
Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke.
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Sodium channel blocker
Metaflumizone is a semicarbazone insecticide, acts as a potent sodium channel blocker.
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calcium channel blocker
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
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Gardos channel blocker
Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker with IC50 value of 11 nM. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
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Piezo1 channel antagonist
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel.
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Calcium channel antagonist
Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects.
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Calcium channel blocker
Lercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.
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Calcium channel blocker
Fendiline hydrochloride is a nonselective calcium channel blocker.
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Calcium channel blockers
Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
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Potassium channel blocker
Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk.
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Calcium channel blocker
Efonidipine is a dihydropyridine calcium channel blocker that blocks both T-type and L-type calcium channels. It has also been studied in atherosclerosis and acute renal failure.
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K+ channel and CFTR Cl- channel blocker
Glyburide (Glibenclamide) 是一种抗糖尿病化合物,是一类磺脲类药物。
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Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) is an activator of signal transduction of G proteins.
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Auranofin is a gold salt classified by the World Health Organization as an antirheumatic agent. It is a gold-thiol complex with anti-inflammatory and immunosuppressive actions.
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Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits NF-κB activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.
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Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively.
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digest GST-tagged proteins
Thrombin is a trypsin-like allosteric serine protease. Thrombin enables site-specific cleavage of fusion proteins with an accessible Thrombin recognition sequence and can be used to digest GST-tagged proteins.
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unique pigment
Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.
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FLT3 inhibitor
HM-43239 is a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations
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Cinnamylamine can be used for the preparation of Tranylcypromine, a drug that acts as a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO), and is used as an antidepressant and anxiolytic agent.
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Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
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DNA G-quadruplexe (G4) ligand
BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
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TLR4 inhibitor
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
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PD-1/PD-L1 interaction inhibitor
BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM.
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