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Duocarmycin MB
Catalog No. A19799 ADCs toxinDuocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines. 了解更多 -
ATRA-hydroxyimino
Catalog No. A19791 ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells. 了解更多 -
PROTAC CRABP-II Degrader-1
Catalog No. A19782 CRABP-II degraderPROTAC CRABP-II Degrader-1 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1. 了解更多 -
Calcein Blue
Catalog No. A19780 blue-fluorescent dyeCalcein Blue is a short-term, blue-fluorescent dye for labeling live cells. 了解更多 -
PROTAC CRABP-II Degrader-2
Catalog No. A19773 CRABP-II degraderPROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1. 了解更多 -
Nampt-IN-3
Catalog No. A19769 NAMPT inhibitorNampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. 了解更多 -
PROTAC CRABP-II Degrader-3
Catalog No. A19764 CRABP-II degraderPROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1. 了解更多 -
TRAF-STOP inhibitor 6877002
Catalog No. A19758 CD40-TRAF6 interaction inhibitorTRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. 了解更多 -
4-Octyl Itaconate
Catalog No. A19731 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. 了解更多 -
Dihydrofluorescein diacetate
Catalog No. A19726 fluorimetric probeDihydrofluorescein diacetate is a fluorimetric probe mainly used for oxidative stress measurements, in both cell-free systems and cellular models. 了解更多 -
KDM2A/7A-IN-1
Catalog No. A19724 KDM2A/7A inhibitorKDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. 了解更多 -
N-Acetylcysteine amide
Catalog No. A19719 N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production. 了解更多 -
Real Thiol
Catalog No. A19652 fluorescent probeReal Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells. 了解更多 -
VU0529331
Catalog No. A19614 potassium channel (non-GIRK1/X) activatorVU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel. 了解更多 -
Heparan Sulfate
Catalog No. A19609 Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix. 了解更多 -
(S,R,S)-AHPC TFA
Catalog No. A19593 (S,R,S)-AHPC TFA (MDK7526 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (MDK7526 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. 了解更多 -
Cefotetan disodium
Catalog No. A19589 Cefotetan disodium is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. 了解更多 -
2,2,5,7,8-Pentamethyl-6-Chromanol
Catalog No. A19565 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines. 了解更多 -
BAY-678 racemate
Catalog No. A19564 HNE inhibitorBAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). 了解更多 -
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
Catalog No. A19540 protease inhibitorN-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death. 了解更多 -
D-Ala-Lys-AMCA
Catalog No. A19387 D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. 了解更多 -
Inarigivir soproxil
Catalog No. A19335 innate immunity agonistInarigivir soproxil is an agonist of innate immunity and shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. 了解更多 -
trans-Ned 19
Catalog No. A19327 NAADP antagonist and TPC blockertrans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations. 了解更多
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