CRM1

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  1. KPT185

    Catalog No. A12975
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    CRM1 抑制剂
    KPT185是选择性CRM1抑制剂。KPT-185以100 nM至500 nM的IC50显着抑制白血病细胞增殖,并诱导AML细胞系和原发性AML原始细胞的细胞周期停滞和凋亡。 了解更多
  2. Selinexor (KPT-330)

    Catalog No. A12582
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    CRM1 抑制剂
    CRM1(XPO1)介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。 了解更多
  3. KPT276

    Catalog No. A16341
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    SINE/CRM1 抑制剂
    KPT276是KPT-185的类似物,是核出口(SINE)和CRM1的选择性抑制剂。 了解更多
  4. Eltanexor Z-isomer

    Catalog No. A21786
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    CRM1 inhibitor
    Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. 了解更多
  5. Leptomycin B

    Catalog No. A20985
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    nuclear export receptor CRM1 inhibitor
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. 了解更多

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