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CUDC-907 (Fimepinostat)

Catalog No. A11153
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PI3K/HDAC 抑制剂

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。了解更多

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- Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889
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MGCD0103 (Mocetinostat)

Catalog No. A10586
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HDAC 抑制剂

MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂，主要抑制组蛋白脱乙酰基酶1（HDAC1），但也抑制HDAC2，HDAC3和HDAC11。了解更多

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- Mari Ishigami-Yuasa, .et al. Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer, Biol Pharm Bull, 2019, 42, 448-452
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
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MS-275 (Entinostat)

Catalog No. A10611
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HDAC 抑制剂

MS-275 (Entinostat)是一种有效的HDAC抑制剂，对HDAC1和HDAC3的IC50分别为0.3和8uM。了解更多

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- Vivek Bora, .et al. Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia, Can J Physiol Pharmacol, 2021, 6 October
- Taito Kashio, .et al. HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells, Tissue Barriers, 2021, May 6;1911195 PMID: 33955828
- Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- Arshdeep Singh, .et al. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition, Eur J Med Chem, 2021, Apr 5;215:113169 PMID: 33588178
- Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096
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CI994 (Tacedinaline)

Catalog No. A11964
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HDAC 抑制剂

CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。了解更多

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Droxinostat

Catalog No. A10337
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HDAC 抑制剂

Droxinostat是HDAC3，HDAC6和HDAC8的选择性抑制剂，显示出可比较的HDAC6和HDAC8抑制作用，IC50分别为2.47和1.46μmol/ L。了解更多

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Trichostatin-A (TSA)

Catalog No. A10947
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HDAC 抑制剂

Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10，IC50值约为20 nM。了解更多

Product Citations (3)

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- Goudreault M, .et al. Afadin couples RAS GTPases to the polarity rheostat Scribble, Research Square, 2021, 22 Nov
- Hiroyuki Imuta, .et al. Histone methylation and demethylation are implicated in the transient and sustained activation of the interleukin-1β gene in murine macrophages, Heart Vessels, 2020, Jul 16 PMID: 32676696
- M??ndez-Blanco C, .et al. Stabilization of Hypoxia-Inducible Factors and BNIP3 Promoter Methylation Contribute to Acquired Sorafenib Resistance in Human Hepatocarcinoma Cells, Cancers (Basel), 2019, Dec 9;11(12). pii: E1984 PMID: 31835431