β-Amyloid

Catalog No.Inhibitor Name Beta AmyloidOther
A10288DAPT (GSI-IX)
**
A10802RO4929097
***
γ secretase,γ secretase(ICN)
A11194MK-0752
***
A10157Avagacestat
****
A11776LY2811376
*
BACE1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Ro 90-7501

    Catalog No. A12647
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    amyloid β42 抑制剂
    Ro 90-7501是淀粉样蛋白β42(Aβ42)原纤维组装的抑制剂;降低Aβ42诱导的毒性(EC50 = 2μM)。 了解更多
  2. LY2811376

    Catalog No. A11776
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    BACE1 抑制剂
    LY2811376是第一种可口服的非肽类BACE1抑制剂,可在动物体内产生显着的Aβ降低作用。 了解更多
  3. MK-0752

    Catalog No. A11194
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    Gamma-secretase 抑制剂
    MK-0752抑制Notch信号通路,这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。 了解更多
  4. BMS-708163 (Avagacestat)

    Catalog No. A10157
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    Gamma-secretase 抑制剂
    BMS-708163 (Avagacestat)是口服生物有效的,选择性的γ-分泌酶抑制剂,作用于Aβ40和Aβ42时,IC50分别为0.3 nM和0.27 nM。 了解更多
  5. RO4929097

    Catalog No. A10802
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    Gamma-secretase 抑制剂
    RO4929097是一种γ secretase抑制剂,无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工,EC50分别为14 nM和5 nM。 了解更多
  6. gamma-Secretase Modulators

    Catalog No. A11426
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    Amyloid-β production inhibitor
    gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. 了解更多

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