Lapatinib (free base)

目录号: A11752

Lapatinib (free base)

Lapatinib (free base) Chemical Structure

CAS NO. 231277-92-2

Lapatinib (free base)是一种双重酪氨酸激酶抑制剂,是一种有效的EGFR和ErbB2抑制剂,在无细胞试验中IC50分别为10.2和9.8 nM。可阻断HER2生长受体途径。

库存: 现货

规格 价格 数量
10 mg
¥ 210.00
25 mg
¥ 280.00
50 mg
¥ 350.00
100 mg
¥ 490.00
10mM * 1mL in DMSO
¥ 350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Lapatinib (free base)是一种双重酪氨酸激酶抑制剂,是一种有效的EGFR和ErbB2抑制剂,在无细胞试验中IC50分别为10.2和9.8 nM。可阻断HER2生长受体途径。
Targets
Target Value
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM
In vitro (25°C) DMSO 99 mg/mL (170.37 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.21 mL 86.04 mL 172.09 mL
0.5 mM 3.44 mL 17.21 mL 34.42 mL
1 mM 1.72 mL 8.6 mL 17.21 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11752
M. Wt 581.1
Formula C29H26ClFN4O4S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 231277-92-2
SMILES CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

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