P276-00

目录号: A13547

CDK 抑制剂

P276-00

P276-00 Chemical Structure

CAS NO. 920113-03-7

P276-00是一种新型CDK1,CDK4和CDK9抑制剂,IC50分别为79 nM,63 nM和20 nM。在第2/3阶段。

库存: 现货

规格 价格 数量
5 mg
¥ 1,260.00
10 mg
¥ 2,100.00
25 mg
¥ 3,850.00
10mM * 1mL in DMSO
¥ 1,470.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

P276-00是一种新型CDK1,CDK4和CDK9抑制剂,IC50分别为79 nM,63 nM和20 nM。在第2/3阶段。
Targets
Target Value
CDK9/CyclinT1IC50: 20nM
CDK4/CyclinD1IC50: 63nM
CDK1/CyclinBIC50: 79nM
CDK2/CyclinAIC50: 224nM
CDK6/CyclinD3IC50: 396nM
CDK2/CyclinEIC50: 2.54μM
GSK-3βIC50: 2.771μM
CDK7/CyclinHIC50: 2.87μM
c-SrcIC50: <10μM
PKCαIC50: 10μM
MAPK1IC50: 22μM
PKCIC50: 25μM
MAPK2IC50: >100μM
PKAIC50: 575μM
In vitro (25°C) DMSO 79 mg/mL (180.24 mM)
Water 79 mg/mL (180.24 mM)
Ethanol 6 mg/mL (13.69 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13547
作用机制 Inhibitor (抑制剂)
M. Wt 438.3
Formula C21H20ClNO5.HCl
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 920113-03-7
Synonyms P276, P276-00
SMILES CN1CC[C@H]([C@@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

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