PKC 412 (Midostaurin)

目录号: A12650

PKC 抑制剂

PKC 412 (Midostaurin)

PKC 412 (Midostaurin) Chemical Structure

CAS NO. 120685-11-2

PKC 412 (Midostaurin)是一种广谱蛋白激酶抑制剂。抑制常规PKC亚型α/β/γ,PDFRβ,VEGFR2,Syk,Flk-1,Flt3,Cdk1/B,PKA,c-Kit,c-Fgr,c-Src,VEGFR1和EGFR。显示有效的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 630.00
10 mg
¥ 1,015.00
25 mg
¥ 1,820.00
50 mg
¥ 2,835.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PKC 412 (Midostaurin)是一种广谱蛋白激酶抑制剂。抑制常规PKC亚型α/β/γ,PDFRβ,VEGFR2,Syk,Flk-1,Flt3,Cdk1/B,PKA,c-Kit,c-Fgr,c-Src,VEGFR1和EGFR。显示有效的抗肿瘤活性。
Targets
Target Value
PKCαIC50: 22nM
PKCγIC50: 24nM
PKCβ1IC50: 30nM
PKCβ2IC50: 31nM
PPKIC50: 38nM
KDRIC50: 86nM
c-SykIC50: 95nM
PKCηIC50: 160nM
PKCδIC50: 330nM
Flk1IC50: 390nM
CDK1/CyclinBIC50: 570nM
PKAIC50: 570nM
c-FGRIC50: 790nM
c-SrcIC50: 800nM
FLT1IC50: 912nM
PLK1IC50: >1.0μM
p38IC50: >1μM
Tie-1IC50: >1μM
c-MetIC50: >1μM
EGFRIC50: 1.1μM
PKCεIC50: 1.25μM
Myosin-lightchainkinaseIC50: 1.9μM
c-LynIC50: 4.30μM
p70S6KIC50: 5.0μM
CSKIC50: 8.0μM
CDK4/CyclinD1IC50: >10μM
JunkinaseIC50: >10μM
Tie-2IC50: >10μM
FGFR1IC50: >10μM
v-AblIC50: >100μM
ERK1IC50: >200μM
CK1IC50: >200μM
CK2IC50: >200μM
PKBIC50: >300μM
PKCζIC50: 465μM
In vitro (25°C) DMSO 90 mg/mL (157.72 mM)
Water Insoluble
Ethanol Warmed: 18 mg/mL
In vivo 5% DMSO+45% PEG 300+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.52 mL 87.62 mL 175.24 mL
0.5 mM 3.5 mL 17.52 mL 35.05 mL
1 mM 1.75 mL 8.76 mL 17.52 mL
5 mM 0.35 mL 1.75 mL 3.5 mL

*The above data is based on the productmolecular weight 570.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12650
作用机制 Inhibitor (抑制剂)
M. Wt 570.64
Formula C35H30N4O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 120685-11-2
Synonyms CGP 41251, PKC412, PKC-412, CGP41251, CGP-41251
SMILES C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

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