MK-2461

目录号: A11753

c-Met 抑制剂

MK-2461

MK-2461 Chemical Structure

CAS NO. 917879-39-1

MK-2461是一种新型的多靶点激酶抑制剂,优先抑制活化的c-Met受体。

库存: 现货

规格 价格 数量
5 mg
¥ 1,260.00
10 mg
¥ 2,240.00
25 mg
¥ 4,550.00
50 mg
¥ 8,050.00
10mM * 1mL in DMSO
¥ 1,659.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

MK-2461是一种新型的多靶点激酶抑制剂,优先抑制活化的c-Met受体。
Targets
Target Value
c-Met(M1250T)IC50: 0.4nM
c-Met(Y1235D)IC50: 0.5nM
c-Met(Y1230H)IC50: 1.0nM
c-Met(N1100)IC50: 1.5nM
c-Met(Y1230C)IC50: 1.5nM
c-MetIC50: 2.5nM
RONIC50: 7nM
FLT1IC50: 10nM
FLT3IC50: 22nM
PDGFRβIC50: 22nM
MerIC50: 24nM
FGFR2IC50: 39nM
KDRIC50: 44nM
TrkAIC50: 46nM
FGFR3IC50: 50nM
TrkBIC50: 61nM
FGFR1IC50: 65nM
FLT4IC50: 78nM
DRAK1IC50: 199nM
JAK2IC50: 225nM
IRAK4IC50: 298nM
MELKIC50: 606nM
RETIC50: 635nM
DYRK2IC50: 1.143μM
MLK1IC50: 4.303μM
IRAK1IC50: 5.459μM
AblIC50: 7.747μM
In vitro (25°C) DMSO 95 mg/mL (191.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.18 mL 100.89 mL 201.78 mL
0.5 mM 4.04 mL 20.18 mL 40.36 mL
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11753
作用机制 Inhibitor (抑制剂)
M. Wt 495.6
Formula C24H25N5O5S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 917879-39-1
Synonyms MK2461
SMILES CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)C[C@@H]5COCCO5)C(=O)C3=C2

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