Apatinib (YN968D1)

目录号: A11407

VEGFR 抑制剂

Apatinib (YN968D1)

Apatinib (YN968D1) Chemical Structure

CAS NO. 811803-05-1

Apatinib (YN968D1)是一种酪氨酸激酶抑制剂,可选择性抑制血管内皮生长因子受体2(VEGFR2,也称为KDR),后者可抑制VEGF介导的内皮细胞迁移和增殖,从而阻止肿瘤组织中新血管的形成。

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,050.00
50 mg
¥ 2,450.00
100 mg
¥ 3,150.00
10mM * 1mL in DMSO
¥ 770.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Apatinib (YN968D1)是一种酪氨酸激酶抑制剂,可选择性抑制血管内皮生长因子受体2(VEGFR2,也称为KDR),后者可抑制VEGF介导的内皮细胞迁移和增殖,从而阻止肿瘤组织中新血管的形成。
Targets
Target Value
VEGFR2IC50: 1nM
RETIC50: 13nM
c-KitIC50: 429nM
c-SrcIC50: 530nM
PDGFRαIC50: >1μM
EGFRIC50: >10μM
HER2IC50: >10μM
FGFR1IC50: >10μM
In vitro DMSO 77 mg/mL (193.72 mM)
Water Insoluble
Ethanol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.26 mL 101.3 mL 202.59 mL
0.5 mM 4.05 mL 20.26 mL 40.52 mL
1 mM 2.03 mL 10.13 mL 20.26 mL
5 mM 0.41 mL 2.03 mL 4.05 mL

*The above data is based on the productmolecular weight 493.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11407
作用机制 Inhibitor (抑制剂)
M. Wt 493.6
Formula C25H27N5O4S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 811803-05-1
SMILES CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4

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