“leukotriene receptor”的搜索结果
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immune modulator
Anandamide is an immune modulator in the central nervous system acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55).
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sigma-1 receptors modulator
E1R is a novel positive allosteric modulator of sigma-1 receptors.
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mGlu4 receptors modulator
VU 0364770是mGlu4受体的正变构调节剂,在表达mGlu4的HEK 293细胞中EC50值为290 nM。
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mGlu4 receptors modulator
VU 0361737是mGluR-4的选择性正变构调节剂(人和大鼠受体的EC50值分别为240和110 nM)。
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progesterone receptor modulator
Ulipristal (acetate) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
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estrogen receptor modulator
4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
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estrogen receptor modulators
Pipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs).
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A3 adenosine receptor allosteric modulator
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).
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GABA(A) receptor modulator
NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
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glutamate receptor 4 modulator
Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. Antiparkinsonian effect.
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nuclear estrogen receptor modulator
Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator.
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human CX3CR1 receptor modulator
AZD8797 is an allosteric non-competitive and orally active modulator of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
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androgen receptor modulator
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM).
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mGlu4 receptor modulator
TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
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AMPA receptor positive allosteric modulator
PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.
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androgen receptor modulator
GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
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selective estrogen receptor modulator (SERM)
Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.
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IL-1 receptor-associated kinase (IRAK) kinase modulator
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
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endothelin receptor modulator
Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders.
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metabotropic glutamate receptor 4 modulator
VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM.
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mGlu4 receptor modulator
Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
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Progesterone receptor modulator
Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.
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Ryanodine receptor modulator
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
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Thyrotropin receptor modulator
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro.
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selective glucocorticoid receptor modulator
AZD9567 is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM.
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selective Estrogen receptor modulator
Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator.
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liver x receptor (LXR) modulator
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.
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mAChR M5 negative allosteric modulator
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.
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AMPA receptors positive allosteric modulator
CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ?? 4.2 nM/63.4 ?? 5.6 nM for GluA2i/GluA2o receptor.
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AMPA receptors allosteric modulator
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
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positive allosteric modulator
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.
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mAChR modulator
Rapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR).
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GLP-1R modulator
NNC0640 is a negative allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R).
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PPARδ modulator
MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).
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M4 modulator
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders.
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M1 modulator
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM.
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GLP-1R modulator
VU0453379 is a CNS-penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM) with an EC50 of 1.3 μM.
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mGlu5 modulator
VU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM.
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CXCR4 receptor modulator
NSC-23026是CXCR4受体调节剂。
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androgen receptor modulator (SARM)
LY2452473是一种口服生物利用型选择性雄激素受体调节剂(SARM),具有潜在的组织选择性雄激素/抗雄激素活性。
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GABAA receptor modulator
Lorediplon 是一种新型的非苯二氮卓类催眠药,作为GABAA受体调节剂。
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S1P1 receptor modulator
Ponesimod是一种口服活性,选择性鞘氨醇-1-磷酸受体1(S1P1)免疫调节剂,EC50为5.7 nM。
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androgen receptor modulator
GSK-2881078是一种选择性雄激素受体调节剂(SARM),正在针对肌肉萎缩以改善其身体功能的受试者的肌肉生长和力量进行评估。
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mGlu2 receptor modulator
CBiPES HCl是mGluR-2的选择性正变构调节剂,IC50值为98.2 nM。
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Estrogen receptor modulator
Toremifene是正在开发中的第二代选择性雌激素受体调节剂(SERM),用于预防骨质疏松症。
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Androgen receptor modulator
MK-0773是一种选择性雄激素受体调节剂(SARMs),是一种4-氮杂-类固醇,在人体中表现出组织选择性(IC50 = 6.6 nM)。
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GABAA receptor modulator
Indiplon是吡唑并嘧啶,可作为GABAA受体的高亲和力正变构调节剂,以剂量依赖和可逆的方式增强GABA活化的氯离子电流。
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AMPA receptor modulator
Farampator是一种AMPA受体正调节剂,它可以改善短期记忆,但会损害情景记忆。
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estrogen receptor modulator
Ospemifene是一种非激素选择性雌激素受体调节剂(SERM)。
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5-HT3 Receptor Modulator
PU 02是5-HT3受体的负变构调节剂。
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