“leukotriene receptor”的搜索结果
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LTR antagonist
Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
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LTR antagonist
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
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BLT2 receptors 拮抗剂
LY 255283是一种有效的 BLT2 receptors 拮抗剂。
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CXCR3 antagonist
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3.
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CXCR3 antagonist
SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
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CXCR3 antagonist
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
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CCR4 antagonist
GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96????0.11.
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CCR4 拮抗剂
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.
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CCR3 拮抗剂
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.
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CCR2 /CCR5 dual 拮抗剂
PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema.
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CXCR4 拮抗剂
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.
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IL-1 receptor 拮抗剂
AF 12198是人I型白介素1(IL-1)受体的有效选择性拮抗剂。
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interleukin-5 receptor 拮抗剂
YM-90709是白介素5受体拮抗剂。YM-90709抑制IL-5与其周围人嗜酸性粒细胞和丁酸处理的嗜酸性HL-60克隆15细胞的受体结合,IC50值分别为1.0和0.57 microM。
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CysLT1 receptor 拮抗剂
MK-571 sodium salt是一种选择性的口服活性CysLT1受体拮抗剂。它阻断LTD4而不是LTC4与人和豚鼠肺膜的结合,Ki值分别为0.22 nM和2.1 nM。
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CysLT1 receptor 拮抗剂
MK-571是有效的CysLT1(LTD4)白三烯受体反向激动剂,EC50值为1.3 nM。
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- Jung-Hung Chen, .et al. Transplacental transfer of acetaminophen in pregnant rats, Biomed Pharmacother, 2022, Oct;154:113613 PMID: 36058146
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LTD4 receptor 拮抗剂
MK-0679 (Verlukast)是有效的白三烯D4拮抗剂。
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