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搜索结果：“jwh 249”

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SB 334867

Catalog No. A12786
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OX1 receptor 拮抗剂

SB 334867是一种选择性的非肽orexin OX1受体拮抗剂。对于分别表达人OX1和OX2受体的CHO细胞中的细胞内Ca2 +释放抑制，pKb值为7.2和<5。体内全身给药后，阻断orexin-A诱导的美容和进食。了解更多

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- Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
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SB225002

Catalog No. A14209
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CXCR2 拮抗剂

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。了解更多

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Toreforant

Catalog No. A21058
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histamine H4 receptor (H4R) antagonist

Toreforant is a potent and selective histamine H4 receptor (H4R) antagonist, with a Ki at the human receptor of 8.4 nM. 了解更多

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Methoxy-PEPy

Catalog No. A21899
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mGlu5 receptor antagonist

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM. 了解更多

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