“betaine hydrochloride”的搜索结果
-
Serotonin 5HT3-receptor antagonist
Alosetron Hydrochloride(1:X) (GR 68755 Hydrochloride(1:X)) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
了解更多
-
CGRP1 receptor antagonist
Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP.
了解更多
-
non-peptide CCR1 antagonist
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
了解更多
-
adrenoceptor antagonist
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity?=?255:1, a half-life of 4?min)?? acts as an adrenoceptor antagonist.
了解更多
-
CaSR antagonist
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist.
了解更多
-
5-HT (serotonin) and dopamine receptor antagonist
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
了解更多
-
α2 adrenoceptor antagonist
Piperoxan hydrochloride is an α2 adrenoceptor antagonist.
了解更多
-
5-HT7 receptor antagonist
SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
了解更多
-
Acid pump antagonist
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection.
了解更多
-
NK3 receptor 拮抗剂
Talnetant Hydrochloride是一种有效且选择性的NK3受体拮抗剂(ki = 1.4 nM,hNK-3-CHO);对hNK-3受体的选择性是对hNK-2受体的100倍,在浓度高达100 uM时对hNK-1没有亲和力。
了解更多
-
D3/D2 Dopamine Receptor 拮抗剂
Cariprazine hydrochloride是一种新型的抗精神病药物,对多巴胺D3(Ki = 0.09 nM)和D2(Ki = 0.5 nM)受体具有高选择性和亲和力,对5-羟色胺5-HT(1A)受体具有中等亲和力。
了解更多
-
dopamine D2/D3 receptor antagonist
Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
了解更多
-
5-HT1B receptor antagonist
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
了解更多
-
NMDA receptor antagonist
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
了解更多
-
LTB4 antagonist
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity.
了解更多
-
dopamine D2 receptor antagonist
Risperidone hydrochloride is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, with Kis of 0.16, 1.4 nM for 5-HT2 and D2 receptor, respectively.
了解更多
-
mAChR antagonist
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.
了解更多
-
5-HT2C receptor antagonist
SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.
了解更多
-
CCR2 antagonist
RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1.
了解更多
-
5-HT2 antagonist
Sarpogrelate hydrochloride (MCI-9042), a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
了解更多
-
5-HT (serotonin)/dopamine receptor antagonist
Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
了解更多
-
5-HT6 receptor antagonist
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
了解更多
-
β-adrenergic receptor antagonist
Metipranolol (hydrochloride) is a non-selective β-adrenergic receptor (β-AR) antagonist. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
了解更多
-
5-HT1A receptor antagonist
Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.
了解更多
-
Muscarinic antagonist
Procyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism.
了解更多
-
AMPA 拮抗剂
YM90K hydrochloride是一种选择性AMPA受体拮抗剂,在局部缺血后给药后,可延迟整体缺血模型中的神经元死亡和局部缺血模型中的脑梗塞。
了解更多
-
GPIIb/IIIa 拮抗剂
Tirofiban Hydrochloride Hydrate是一种特定的非肽血小板纤维蛋白原受体(GPIIb/IIIa)拮抗剂。
了解更多
-
5-HT1A receptor 拮抗剂
NAD 299 hydrochloride (Robalzotan)是一种选择性的,高亲和力的5-HT1A受体拮抗剂(体外Ki = 0.6 nM)。
了解更多
-
5-HT2/5-HT1 拮抗剂
Mianserin hydrochloride是5-HT2/5-HT1拮抗剂。对5-HT6非选择性5-HT2受体拮抗剂具有中等亲和力。对5-HT6具有中等亲和力。
了解更多
-
μ-opioid receptor (MOR) antagonist
GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist.
了解更多
-
estrogen receptor covalent antagonist
H3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA).
了解更多
-
Dopamine D2 antagonist
Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.
了解更多
-
nAChR antagonist
Mecamylamine hydrochloride is a nAChR antagonist previously used to treat hypertension. It displays a wide variety of activities, including reducing depression-like behaviors in subjects with Tourette's syndrome and improving rates of smoking cessation.
了解更多
-
5-HT1F 激动剂
LY 334370 hydrochloride是一种选择性的5-HT1F受体激动剂(Ki值为1.87、16.4,> 100 (IC50))。CAS:199673-74-0(LY 334370盐酸盐);182563-08-2(LY 334370游离碱)
了解更多
-
AMPA 拮抗剂
GYKI53655 Hydrochloride是一种非竞争性AMPA和海藻酸酯受体拮抗剂。
了解更多
-
CXCR4 拮抗剂
在CXCR4 125I-SDF抑制结合试验中,AMD-070 HCl是一种有效的选择性CXCR4拮抗剂,IC50值为13 nM,抑制T-4型HIV-1(NL4.3株)在MT-4细胞中的复制和PBMC。
了解更多
-
α2- adrenoceptor 拮抗剂 / I2 imidazoline receptor 激动剂
Idazoxan hydrochloride 是α2-AR肾上腺素受体拮抗剂和潜在I2咪唑啉受体激动剂。还显示I1咪唑啉受体拮抗剂活性。(I1、I2和α的公钥基础设施值分别为5.90、7.22、8.01、7.43和7.7)。
了解更多
-
Adrenergic α1 Receptor 拮抗剂
HEAT hydrochloride (BE 2254)是一种选择性很强的α1-肾上腺素受体拮抗剂,是3-[125I]-衍生物的前体。肾上腺素受体或肾上腺素能受体是参与多种交感神经系统过程的G蛋白偶联受体。
了解更多
-
β2 adrenergic 拮抗剂
ICI 118,551 hydrochloride是选择性的β2 adrenergic receptor 拮抗剂,结合 β2,β1 和 β3 肾上腺素能受体的Ki 值分别为 0.7,49.5 和 611 nM。
了解更多
-
α-adrenergic (AR) 拮抗剂/CaM 抑制剂
Phenoxybenzamine hydrochloride是一种细胞可渗透的,非特异性的,不可逆的α-肾上腺素(AR)拮抗剂,也可作为CaM抑制剂。
了解更多
-
5-HT3 receptor 拮抗剂
Granisetron Hydrochloride是血清素5-ht3受体拮抗剂。
了解更多
-
AMPAR antagonist
Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
了解更多
-
NK1 receptor antagonist
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist.
了解更多
-
dopamine D2 receptor antagonist
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.
了解更多
-
CP-AMPA receptors antagonist
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
了解更多
-
dopamine D3 receptor antagonist
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
了解更多
-
KOR antagonist
JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
了解更多
-
M1 muscarinic receptor antagonist
Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
了解更多
-
L-isomer of cetirizine and histamine H1 receptor antagonist
Levocetirizine dihydrochloride is a L-isomer of cetirizine and histamine H1 receptor antagonist. It incrases levels of CD4+ CD25+ T cells and decreases levels of eosinophils, decreasing allergy symptoms.
了解更多
-
L-type 拮抗剂
Lomerizine dihydrochloride是L型和T型Ca2+通道和TRp5通道的拮抗剂,用于治疗偏头痛和眩晕。
了解更多